Efficacy of dietary nitrate-rich beetroot juice supplementation in patients with chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis
Alshafie S, El-Helw GO, Fayoud AM, Elrashedy AA, Gbreel MI, Alfayoumi SS, Mohamed IM, Abdelwadoud GT, Isa AS, Ragab KM, Nourelden AZ
Clinical nutrition ESPEN · 13 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-02-07 · Clin Nutr ESPEN · vol. 42 · págs. 32–40
- Editorial
- Elsevier BV
- Citado
- 24 citas · más que el 71% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- De pago
- Áreas de investigación
- Chronic Obstructive Pulmonary Disease (COPD) Research · Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects
- Palabras clave
- chronic obstructive pulmonary disease, beetroot juice, dietary nitrate, nitric oxide, exercise capacity, Borg rating of perceived exertion, blood pressure, oxygen consumption, 6-minute walk test, cycling endurance
- MeSH
- humans, beta vulgaris, pulmonary disease, chronic obstructive, nitrates, cross-over studies, dietary supplements
11 autores
- Somia Alshafie🇪🇬Suez Canal University
- Ghidaa Osama El-Helw🇪🇬Beni-Suef University
- Aya Mamdouh Fayoud🇪🇬Kafrelsheikh University
- Asmaa Ahmed Elrashedy🇪🇬Kafrelsheikh University
- Mohamed Ibrahim Gbreel🇪🇬October 6 University
- Saba Saleh Alfayoumi🇯🇴University of Jordan
- Islam Mayhoub Mohamed🇪🇬Beni-Suef University
- Gehad Taha Abdelwadoud🇪🇬Fayoum University
- Alaa Saad Isa🇪🇬Al-Azhar University
- Khaled Mohamed Ragab🇪🇬Minia University
- Anas Zakarya Nourelden🇪🇬 · autor de correspondenciaAl-Azhar University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory lung disease causing airflow obstruction from the lungs reducing exercise tolerance. It is one of the leading causes of respiratory dysfunction worldwide. Nitric Oxide (NO) may have a significant role in this inflammatory reaction to improve exercise capacity.
Aim
To evaluate the effect of dietary nitrate ingestion for COPD patients.
Methods
We searched Scopus, PubMed, Cochrane, and Web of Science databases till August 2020 and updated the search in December 2020 using relevant keywords. All search results were screened for eligibility. We extracted the data from the included articles and pooled them as mean difference (MD) with a 95% confidence interval (CI), using Review Manager software (ver. 5.4).
Results
A pooled analysis from eight included trials showed no significant difference between dietary nitrate-rich beetroot juice and placebo in systolic blood pressure, diastolic blood pressure, heart rate, 6-min walk test, cycling ergometry endurance time, and maximum rate of oxygen consumption (VO2). On the other hand, nitrate-rich beetroot juice significantly increased the Borg Rating of Perceived Exertion (RPE) scale more than the placebo (MD = -0.77; 95% CI [0.18, 1.37], P = 0.01).
Conclusion
There is no significant effect of nitrate-rich beetroot juice on cardiovascular events as systolic, diastolic blood pressure, and heart rate, or exercise performance as 6-min walk test, and cycling ergometry endurance time, or maximum rate of oxygen consumption (VO2). On the other hand, nitrate-rich beetroot juice improves the Borg Rating of Perceived Exertion (RPE) scale reflecting an increased exercise and physical activity level.
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