The effects of magnesium supplementation on serum level of brain derived neurotrophic factor (BDNF) and depression status in patients with depression
Afsharfar M, Shahraki M, Shakiba M, Asbaghi O, Dashipour A
Clinical nutrition ESPEN · 20 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Zahedan University of Medical Sciences
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-01-25 · Clin Nutr ESPEN · vol. 42 · págs. 381–386
- Editorial
- Elsevier BV
- Citado
- 29 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Treatment of Major Depression · Trace Elements in Health
- Palabras clave
- magnesium supplementation, magnesium oxide, brain-derived neurotrophic factor, depression, serum magnesium, serum BDNF, Beck Depression Inventory, dietary intervention
- MeSH
- humans, magnesium, brain-derived neurotrophic factor, double-blind method, depression, dietary supplements
5 autores
- Maryam Afsharfar🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
- Mansour Shahraki🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
- Mansour Shakiba🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
- Omid Asbaghi🇮🇷 · autor de correspondenciaLorestan University of Medical Sciences
- Alireza Dashipour🇮🇷 · autor de correspondenciaZahedan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Recent researches suggest that there is a relationship between the pathogenesis of depression and serum Brain Derived Neurotrophic Factor (BDNF) levels. Therefore, the purpose of this clinical trial was to determine effect of magnesium supplementation on serum Level of BDNF, magnesium and depression status in patients with depression.
Methods
A double blind randomized clinical trial was conducted on 46 depressed subjects. The participants were randomly allocated into the magnesium (MG) and the placebo (PG) group and received 500 mg magnesium and placebo daily for 8 weeks. Beck's test was conducted and blood samples were taken at baseline and after the intervention period for analysis of serum magnesium and BDNF.
Results
No significant differences were observed in assessed variables between the two groups at the baseline. At the end of intervention, supplementation with magnesium oxide had a significant effect on Beck's test (P = 0.01) and serum magnesium (P = 0.001), but had no significant effect on BDNF levels (P = 0.507) between the two groups.
Conclusions
Daily intake of 500 mg magnesium oxide for at least 8 weeks improved Beck's test score and serum magnesium in depressed patients, but had no significant effect on BDNF levels between the two groups, Which Further research is recommended.
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