Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury
Martínez-Molina N, Siponkoski ST, Kuusela L, Laitinen S, Holma M, Ahlfors M, Jordan-Kilkki P, Ala-Kauhaluoma K, Melkas S, Pekkola J, Rodríguez-Fornells A, Laine M, Ylinen A, Rantanen P, Koskinen S, Cowley BU, Särkämö T
Neural plasticity · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Helsingin Yliopisto
- Gobierno
- Kela
- Gobierno
- Academy of Finland
- Organización sin fines de lucro
- Yrjö Johansson Foundation
- Gobierno
- Social Insurance Institution of Finland
- Universidad u hospital
- University of Helsinki
- Organización sin fines de lucro
- Finnish Association of People with Physical Disabilities and Helsinki Uusimaa Hospital district
- Subvenciones
- Academy of Finland (154/13/01/2016); Helsingin Yliopisto (154/13/01/2016); Kela (299044); Academy of Finland (313/51/2013); Kela (18/26/2013); Kela (154/13/01/2016); Kela (461/13/01/00/2015); Academy of Finland (461/13/01/00/2015); Academy of Finland (18/26/2013); Kela (306625); Helsingin Yliopisto (277693); Helsingin Yliopisto (306625); Kela (313/51/2013); Helsingin Yliopisto (18/26/2013); Academy of Finland (306625); Helsingin Yliopisto (299044); Academy of Finland (277693); Helsingin Yliopisto (313/51/2013); Kela (277693); Academy of Finland (299044); Helsingin Yliopisto (461/13/01/00/2015)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-03-08 · Neural Plast · vol. 2021 · págs. 1–18
- Editorial
- Hindawi Publishing Corporation
- Citado
- 51 citas · más que el 96% de estudios similares · 4.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 107 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Functional Brain Connectivity Studies · Traumatic Brain Injury Research · Music Therapy and Health
- Palabras clave
- traumatic brain injury, resting-state functional connectivity, network plasticity, executive function, frontoparietal network, dorsal attention network, default mode network, salience network, inferior frontal gyrus, sensorimotor network, cognitive rehabilitation, music processing
- MeSH
- brain, nerve net, humans, magnetic resonance imaging, music therapy, cross-over studies, single-blind method, neuronal plasticity, rest, adult, middle aged, female, male, brain injuries, traumatic
17 autores
- Noelia Martínez‐Molina🇫🇮 · autor de correspondenciaUniversity of Helsinki
- Sini‐Tuuli Siponkoski🇫🇮University of Helsinki
- Linda Kuusela🇫🇮University of Helsinki; Helsinki University Hospital; Hospital District of Helsinki and Uusimaa
- Sari Laitinen
- Milla Holma
- Mirja Ahlfors
- Päivi Jordan-Kilkki
- Katja Ala-Kauhaluoma
- Susanna Melkas🇫🇮University of Helsinki; Helsinki University Hospital
- Johanna Pekkola🇫🇮University of Helsinki; Helsinki University Hospital; Hospital District of Helsinki and Uusimaa
- Antoni Rodríguez‐Fornells🇪🇸Institució Catalana de Recerca i Estudis Avançats; Institut d'Investigació Biomédica de Bellvitge; Universitat de Barcelona
- Matti Laine🇫🇮Åbo Akademi University
- Aarne Ylinen🇫🇮University of Helsinki; Helsinki University Hospital; Tampere University Hospital
- Pekka Rantanen🇫🇮Helsinki University Hospital; Kanta-Hämeen Keskussairaala
- Sanna K. Koskinen🇫🇮University of Helsinki
- Benjamin Ultan Cowley🇫🇮University of Helsinki
- Teppo Särkämö🇫🇮University of Helsinki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Traumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. In our previous randomized controlled trial, we found that a 3-month neurological music therapy intervention enhanced executive function (EF) and increased grey matter volume in the right inferior frontal gyrus (IFG) in patients with moderate-to-severe TBI (N = 40). Extending this study, we performed longitudinal rsFC analyses of resting-state fMRI data using a ROI-to-ROI approach assessing within-network and between-network rsFC in the frontoparietal (FPN), dorsal attention (DAN), default mode (DMN), and salience (SAL) networks, which all have been associated with cognitive impairment after TBI. We also performed a seed-based connectivity analysis between the right IFG and whole-brain rsFC. The results showed that neurological music therapy increased the coupling between the FPN and DAN as well as between these networks and primary sensory networks. By contrast, the DMN was less connected with sensory networks after the intervention. Similarly, there was a shift towards a less connected state within the FPN and SAL networks, which are typically hyperconnected following TBI. Improvements in EF were correlated with rsFC within the FPN and between the DMN and sensorimotor networks. Finally, in the seed-based connectivity analysis, the right IFG showed increased rsFC with the right inferior parietal and left frontoparietal (Rolandic operculum) regions. Together, these results indicate that the rehabilitative effects of neurological music therapy after TBI are underpinned by a pattern of within- and between-network connectivity changes in cognitive networks as well as increased connectivity between frontal and parietal regions associated with music processing.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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