Red Meat Consumption and Risk of Nonalcoholic Fatty Liver Disease in a Population With Low Meat Consumption: The Golestan Cohort Study
Hashemian M, Merat S, Poustchi H, Jafari E, Radmard AR, Kamangar F, Freedman N, Hekmatdoost A, Sheikh M, Boffetta P, Sinha R, Dawsey SM, Abnet CC, Malekzadeh R, Etemadi A
The American journal of gastroenterology · 51 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- World Health Organization
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- National Institutes of Health
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Institutes of Health (ZIA CP000101)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-03-24 · Am J Gastroenterol · vol. 116 · número 8 · págs. 1667–1675
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 61 citas · más que el 98% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- Medicine, White meat, Red meat, Nonalcoholic fatty liver disease, Odds ratio, Population, Fatty liver, Internal medicine, Quartile, Cohort, Confidence interval, Disease, Environmental health, Food science, Pathology, Biology
- MeSH
- animals, humans, diet, risk factors, meat, adult, aged, middle aged, diet records, iran, female, male, non-alcoholic fatty liver disease
15 autores
- Maryam Hashemian🇺🇸🇮🇷 · autor de correspondenciaUtica College; Tehran University of Medical Sciences
- Shahin Merat🇮🇷Tehran University of Medical Sciences
- Hossein Poustchi🇮🇷Tehran University of Medical Sciences
- Elham Jafari🇮🇷Tehran University of Medical Sciences
- Amir-Reza Radmard🇮🇷Shariati Hospital; Tehran University of Medical Sciences
- Farin Kamangar🇮🇷🇺🇸Tehran University of Medical Sciences; Morgan State University
- Neal D. Freedman🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Azita Hekmatdoost🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Mahdi Sheikh🇫🇷🇮🇷Centre international de recherche sur le cancer; Tehran University of Medical Sciences
- Paolo Boffetta🇺🇸🇮🇹Stony Brook University; University of Bologna
- Rashmi R. Sinha🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Sanford M. Dawsey🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Christian C. Abnet🇺🇸National Cancer Institute; Division of Cancer Epidemiology and Genetics
- Reza Malekzadeh🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Arash Etemadi🇺🇸🇮🇷National Cancer Institute; Division of Cancer Epidemiology and Genetics; Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Nonalcoholic fatty liver disease (NAFLD), as the most common liver disease in the world, can range from simple steatosis to steatohepatitis. We evaluated the association between meat consumption and risk of NAFLD in the Golestan Cohort Study (GCS).
Methods
The GCS enrolled 50,045 participants, aged 40-75 years in Iran. Dietary information was collected using a 116-item semiquantitative food frequency questionnaire at baseline (2004-2008). A random sample of 1,612 cohort members participated in a liver-focused study in 2011. NAFLD was ascertained through ultrasound. Total red meat consumption and total white meat consumption were categorized into quartiles based on the GCS population, with the first quartile as the referent group. Multivariable logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
The median intake of total red meat was 17 and total white meat was 53 g/d. During follow-up, 505 individuals (37.7%) were diagnosed with NAFLD, and 124 of them (9.2%) had elevated alanine transaminase. High total red meat consumption (ORQ4 vs Q1 = 1.59, 95% CI = 1.06-2.38, P trend = 0.03) and organ meat consumption (ORQ4 vs Q1 = 1.70, 95% CI = 1.19-2.44, P trend = 0.003) were associated with NAFLD. Total white meat, chicken, or fish consumption did not show significant associations with NAFLD.
Discussion
In this population with low consumption of red meat, individuals in the highest group of red meat intake were at increased odds of NAFLD. Furthermore, this is the first study to show an association between organ meat consumption and NAFLD (see Visual Abstract, http://links.lww.com/AJG/B944).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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