The effect of omega-3 fatty acid supplementation on clinical and biochemical parameters of critically ill patients with COVID-19: a randomized clinical trial
Doaei S, Doaei S, Gholami S, Rastgoo S, Gholamalizadeh M, Bourbour F, Bagheri SE, Samipoor F, Akbari ME, Shadnoush M, Ghorat F, Mosavi Jarrahi SA, Ashouri Mirsadeghi N, Hajipour A, Joola P, Moslem A, Goodarzi MO
Journal of translational medicine · 129 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Guilan University of Medical Sciences
- Universidad u hospital
- Sabzevar University of Medical Sciences
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-03-29 · J Transl Med · vol. 19 · número 1 · pág. 128
- Editorial
- BioMed Central
- Citado
- 197 citas · más que el 100% de estudios similares · 22.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Fatty Acid Research and Health · COVID-19 Clinical Research Studies
- Palabras clave
- omega-3 polyunsaturated fatty acids, COVID-19 pandemic, critically ill patients, dietary supplementation, enteral formulas, inflammatory markers, acid-base balance, renal function, respiratory function, survival rate, electrolytes
- MeSH
- respiratory system, kidney, humans, critical illness, blood glucose, fatty acids, omega-3, inflammation mediators, blood gas analysis, hematocrit, prognosis, treatment outcome, mortality, survival analysis, double-blind method, dietary supplements, adult, aged, aged, 80 and over, middle aged, iran, female, male, biomarkers, covid-19, sars-cov-2
16 autores
- Saeid Doaei🇮🇷Guilan University of Medical Sciences; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Somayeh Gholami🇮🇷Guilan University of Medical Sciences
- Samira Rastgoo🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Maryam Gholamalizadeh🇮🇷Shahid Beheshti University of Medical Sciences
- Fatemeh Bourbour🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Seyedeh Elaheh Bagheri🇮🇷Guilan University of Medical Sciences
- Forough Samipoor🇮🇷Guilan University of Medical Sciences
- Mohammad Esmail Akbari🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Mahdi Shadnoush🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Fereshteh Ghorat🇮🇷Sabzevar University of Medical Sciences
- Seyed Alireza Mosavi Jarrahi🇮🇷Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Narjes Ashouri Mirsadeghi🇮🇷National Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
- Azadeh Hajipour🇮🇷Qazvin University of Medical Sciences
- Parvin Joola🇮🇷Dezful University of Medical Sciences
- Alireza Moslem🇮🇷 · autor de correspondenciaSabzevar University of Medical Sciences
- Mark O. Goodarzi🇺🇸Cedars-Sinai Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Omega-3 polyunsaturated fatty acids (n3-PUFAs) may exert beneficial effects on the immune system of patients with viral infections. This paper aimed to examine the effect of n3-PUFA supplementation on inflammatory and biochemical markers in critically ill patients with COVID-19.
Methods
A double-blind, randomized clinical trial study was conducted on 128 critically ill patients infected with COVID-19 who were randomly assigned to the intervention (fortified formula with n3-PUFA) (n = 42) and control (n = 86) groups. Data on 1 month survival rate, blood glucose, sodium (Na), potassium (K), blood urea nitrogen (BUN), creatinine (Cr), albumin, hematocrit (HCT), calcium (Ca), phosphorus (P), mean arterial pressure (MAP), O2 saturation (O2sat), arterial pH, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate (HCO3), base excess (Be), white blood cells (WBCs), Glasgow Coma Scale (GCS), hemoglobin (Hb), platelet (Plt), and the partial thromboplastin time (PTT) were collected at baseline and after 14 days of the intervention.
Results
The intervention group had significantly higher 1-month survival rate and higher levels of arterial pH, HCO3, and Be and lower levels of BUN, Cr, and K compared with the control group after intervention (all P 2, PCO2, WBCs, GCS, Hb, Plt, PTT, and albumin between two groups.
Conclusion
Omega-3 supplementation improved the levels of several parameters of respiratory and renal function in critically ill patients with COVID-19. Further clinical studies are warranted. Trial registry Name of the registry: This study was registered in the Iranian Registry of Clinical Trials (IRCT); Trial registration number: IRCT20151226025699N3; Date of registration: 2020.5.20; URL of trial registry record: https://en.irct.ir/trial/48213.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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