Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration
Kozłowska M, Kortas J, Żychowska M, Antosiewicz J, Żuczek K, Perego S, Lombardi G, Ziemann E
Scientific reports · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Centre OPUS 13
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-03-29 · Sci Rep · vol. 11 · número 1 · pág. 7097
- Editorial
- Nature Portfolio
- Citado
- 20 citas · más que el 83% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Adipose Tissue and Metabolism · Exercise and Physiological Responses · Fibroblast Growth Factor Research
- Palabras clave
- Myostatin, Internal medicine, Endocrinology, Myokine, Adiponectin, Glucose homeostasis, Valine, Hyperinsulinemia, Medicine, Homeostasis, Insulin, Insulin resistance, Biology, Amino acid, Muscle hypertrophy, Skeletal muscle, Biochemistry
- MeSH
- humans, glucose, amino acids, cryotherapy, homeostasis, adult, female, male, myostatin, young adult
8 autores
- Marta Kozłowska🇵🇱Gdansk University of Physical Education and Sport
- Jakub Antoni Kortas🇵🇱Gdansk University of Physical Education and Sport
- Małgorzata Żychowska🇵🇱Kazimierz Wielki University in Bydgoszcz
- Jędrzej Antosiewicz🇵🇱Gdańsk Medical University
- Klaudia Żuczek🇵🇱Gdańsk Medical University
- Silvia Perego🇮🇹IRCCS Ospedale Galeazzi - Sant'Ambrogio; Istituti di Ricovero e Cura a Carattere Scientifico
- Giovanni Lombardi🇮🇹IRCCS Ospedale Galeazzi - Sant'Ambrogio; Istituti di Ricovero e Cura a Carattere Scientifico
- Ewa Ziemann · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, - 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Baseline myostatin correlated significantly with visceral fat area, glucose, insulin, HOMA-IR and irisin (all p < 0.05). The single session of WBC induced temporary changes in AA profile, whereas chronic exposure lowered valine and asparagine concentrations (p < 0.01 and p = 0.01, respectively) compared to the baseline. The chronic WBC reduced fasting glucose (p = 0.04), FGF21 (- 35.8%, p = 0.06) and myostatin (-18.2%, p = 0.06). Still, the effects were age-dependent. The decrease of myostatin was more pronounced in middle-aged participants (p < 0.01). Concentrations of irisin and adiponectin increased in response to chronic WBC, while BDNF level remained unchanged. By improving the adipo-myokine profile, chronic WBC may reduce effectively the risk of the metabolic syndrome associated with hyperinsulinemia, increased levels of valine and asparagine, and muscle atrophy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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