Time-Restricted Eating for 12 Weeks Does Not Adversely Alter Bone Turnover in Overweight Adults
Lobene AJ, Panda S, Mashek DG, Manoogian ENC, Hill Gallant KM, Chow LS
Nutrients · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Indiana Clinical and Translational Sciences Institute
- Universidad u hospital
- Healthy Foods, Healthy Lives Institute, University of Minnesota
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (TL1 TR002531); National Center for Advancing Translational Sciences (UL1TR002529); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK124484); Indiana Clinical and Translational Sciences Institute (TL1 TR002531); National Center for Advancing Translational Sciences ((UL1-TR002494)); Indiana Clinical and Translational Sciences Institute (UL1TR002529); Indiana Clinical and Translational Sciences Institute (UL1TR002529, TL1TR002531); National Institute of Diabetes and Digestive and Kidney Diseases (K01DK102864); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK118278); Healthy Foods, Healthy Lives Institute, University of Minnesota (17SFR-2YR50LC)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-03-31 · Nutrients · vol. 13 · número 4 · pág. 1155
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 26 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Circadian rhythm and melatonin
- Palabras clave
- Bone remodeling, Overweight, Endocrinology, Internal medicine, Medicine, N-terminal telopeptide, Bone mineral, Parathyroid hormone, Weight loss, Turnover, Bone resorption, Obesity, Osteoporosis, Chemistry, Calcium, Osteocalcin
- MeSH
- bone and bones, humans, feeding behavior, bone density, time factors, adult, middle aged, female, male, overweight, biomarkers
6 autores
- Andrea J. Lobene🇺🇸 · autor de correspondenciaPurdue University West Lafayette; University of Delaware
- Satchidananda Panda🇺🇸Salk Institute for Biological Studies
- Douglas G. Mashek🇺🇸University of Minnesota
- Emily N. C. Manoogian🇺🇸Salk Institute for Biological Studies
- Kathleen M. Hill Gallant🇺🇸University of Minnesota; Purdue University West Lafayette
- Lisa Senye Chow🇺🇸University of Minnesota
Resumen
El texto original del estudio, en el idioma en que se publicó.
Weight loss is a major focus of research and public health efforts. Time-restricted eating (TRE) is shown to be effective for weight loss, but the impact on bone is unclear. Short-term TRE studies show no effect on bone mineral density (BMD), but no study has measured bone turnover markers. This secondary analysis examined the effect of 12 weeks of TRE vs. unrestricted eating on bone turnover and BMD. Overweight and obese adults aged 18-65 y (n = 20) were randomized to TRE (ad libitum 8-h eating window) or non-TRE. Serum N-terminal propeptide of type I collagen (P1NP), cross-linked N-telopeptide of type I collagen (NTX), and parathyroid hormone (PTH) levels were measured and dual-energy X-ray absorptiometry (DXA) scans were taken pre- and post-intervention. In both groups, P1NP decreased significantly (p = 0.04) but trended to a greater decrease in the non-TRE group (p = 0.07). The treatment time interaction for bone mineral content (BMC) was significant (p = 0.02), such that BMC increased in the TRE group and decreased in the non-TRE group. Change in P1NP was inversely correlated with change in weight (p = 0.04) overall, but not within each group. These findings suggest that TRE does not adversely affect bone over a moderate timeframe. Further research should examine the long-term effects of TRE on bone.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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