Remodeling of the gut microbiome during Ramadan-associated intermittent fasting
Su J, Wang Y, Zhang X, Ma M, Xie Z, Pan Q, Ma Z, Peppelenbosch MP
The American journal of clinical nutrition · 107 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Science and Technology Department of Gansu Province
- Universidad u hospital
- “World-Class Universities and World-Class Disciplines” of Northwest Minzu University
- Universidad u hospital
- Talent Training Project for Kunming University of Science and Technology
- Gobierno
- Gansu Provincial Science and Technology Department
- Gobierno
- Ministry of Science and Technology Assistance Project Grant
- Gobierno
- Changjiang Scholars and Innovative Research Team in University
- Subvenciones
- Science and Technology Department of Gansu Province (1504WKCA094); Science and Technology Department of Gansu Province (17YF1WA166)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2020-11-25 · Am J Clin Nutr · vol. 113 · número 5 · págs. 1332–1342
- Editorial
- Elsevier BV
- Citado
- 142 citas · más que el 98% de estudios similares · 7.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Intermittent fasting, Lachnospiraceae, Microbiome, Feces, Internal medicine, Gut flora, Endocrinology, Physiology, Medicine, Biology, Immunology, Bioinformatics
- MeSH
- feces, humans, bacteria, butyric acid, fasting, cohort studies, islam, adolescent, adult, middle aged, male, young adult, biomarkers, gastrointestinal microbiome
8 autores
- Junhong Su🇨🇳🇳🇱Kunming University of Science and Technology; Erasmus MC
- Yueying Wang
- Xiaofang Zhang🇨🇳Kunming University of Science and Technology
- Mingfu Ma🇨🇳Qinghai No.3 People's Hospital
- Zhenrong Xie🇨🇳Kunming Medical University; First Affiliated Hospital of Kunming Medical University
- Qiuwei Pan🇳🇱Erasmus MC
- Zhongren Ma · autor de correspondencia
- Maikel Petrus Peppelenbosch🇳🇱 · autor de correspondenciaErasmus MC
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting is a popular dietary intervention with perceived relatively easy compliance and is linked to various health benefits, including weight loss and improvement in blood glucose concentrations. The mechanistic explanations underlying the beneficial effects of intermittent fasting remain largely obscure but may involve alterations in the gut microbiota.
Objectives
We sought to establish the effects of 1 mo of intermittent fasting on the gut microbiome.
Methods
We took advantage of intermittent fasting being voluntarily observed during the Islamic faith-associated Ramadan and sampled feces and blood, as well as collected longitudinal physiologic data in 2 cohorts, sampled in 2 different years. The fecal microbiome was determined by 16S sequencing. Results were contrasted to age- and body weight-matched controls and correlated to physiologic parameters (e.g., body mass and calorie intake).
Results
We observed that Ramadan-associated intermittent fasting increased microbiome diversity and was specifically associated with upregulation of the Clostridiales order-derived Lachnospiraceae [no fasting 24.6 ± 13.67 compared with fasting 39.7 ± 15.9 in relative abundance (%); linear discriminant analysis = 4.9, P < 0.001 by linear discriminant analysis coupled with effect size measurements] and Ruminococcaceae [no fasting 13.4 ± 6.9 compared with fasting 23.2 ± 12.9 in relative abundance (%); linear discriminant analysis = 4.7, P < 0.001 by linear discriminant analysis coupled with effect size measurements] bacterial families. Microbiome composition returned to baseline upon cessation of intermittent feeding. Furthermore, changes in Lachnospiraceae concentrations mirrored intermittent fasting-provoked changes in physiologic parameters.
Conclusions
Intermittent fasting provokes substantial remodeling of the gut microbiome. The intermittent fasting-provoked upregulation of butyric acid-producing Lachnospiraceae provides an obvious possible mechanistic explanation for health effects associated with intermittent fasting.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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