Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts
Huang BZ, Wang S, Bogumil D, Wilkens LR, Wu L, Blot WJ, Zheng W, Shu XO, Pandol SJ, Le Marchand L, Setiawan VW
International journal of cancer · 11 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Cancer Society
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (K99CA256525); National Cancer Institute (R01 CA209798); National Cancer Institute (U01 CA164973); National Cancer Institute (U01‐CA202979); American Cancer Society (RSG-16-250-01-CPHPS); National Cancer Institute (P01 CA236585); National Cancer Institute (T32CA229110); National Institutes of Health (U01 CA 202979); National Institutes of Health (U01CA164973); National Institutes of Health (R01CA209798); National Institutes of Health (T32CA229110)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-04-12 · Int J Cancer · vol. 149 · número 4 · págs. 811–819
- Editorial
- Wiley
- Citado
- 18 citas · más que el 82% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Pancreatic and Hepatic Oncology Research · Cancer Risks and Factors · Colorectal Cancer Screening and Detection
- Palabras clave
- Pancreatic cancer, Medicine, Red meat, Prospective cohort study, Cohort study, Cohort, Internal medicine, Cancer, Relative risk, Genotype, Proportional hazards model, Confidence interval, Biology, Pathology, Genetics, Gene
11 autores
- Brian Z. Huang🇺🇸 · autor de correspondenciaUniversity of Southern California; Kaiser Permanente
- Songren Wang🇺🇸University of Southern California
- David Daniel Bogumil🇺🇸University of Southern California
- Lynne Ross Wilkens🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Lang Wu🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- William J. Blot🇺🇸Vanderbilt University Medical Center
- Wei Zheng🇺🇸Vanderbilt University Medical Center
- Xiao‐Ou Shu🇺🇸Vanderbilt University Medical Center
- Stephen Jacob Pandol🇺🇸Cedars-Sinai Medical Center
- Loı̈c Le Marchand🇺🇸University of Hawaiʻi at Mānoa; University of Hawaii System; Cancer Center of Hawaii; University of Hawaii Cancer Center
- Veronica Wendy Setiawan🇺🇸University of Southern California; USC Norris Comprehensive Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
There is limited evidence on the association between red meat consumption and pancreatic cancer among ethnic minorities. We assessed this relationship in two large prospective cohorts: the Multiethnic Cohort Study (MEC) and the Southern Community Cohort Study (SCCS). Demographic, dietary and other risk factor data were collected at cohort entry. Red meat intake was assessed using cohort-specific validated food frequency questionnaires. Incident pancreatic cancer cases were identified via linkages to state cancer registries. Cox regression was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) for the association of red meat intake with pancreatic cancer risk in each cohort. We performed additional analyses to evaluate cooking methods, mutagens and effect modification by NAT1/2 genotypes. From a total of 184 542 (MEC) and 66 793 (SCCS) at-risk participants, we identified 1618 (MEC) and 266 (SCCS) incident pancreatic cancer cases. Red meat consumption was associated with pancreatic cancer risk in the MEC (RRQ4vsQ1 1.18, 95% CI 1.02-1.37) and with borderline statistical significance in the SCCS (RRQ4vsQ1 1.31, 95% CI 0.93-1.86). This association was significant in African Americans (RRQ4vsQ1 1.49, 95% CI 1.06-2.11) and Latinos (RRQ4vsQ1 1.44, 95% CI 1.02-2.04) in the MEC, and among African Americans (RRQ4vsQ1 1.55, 95% CI 1.03-2.33) in the SCCS. NAT2 genotypes appeared to modify the relationship between red meat and pancreatic cancer in the MEC (pinteraction = 0.03). Our findings suggest that the associations for red meat may be strongest in African Americans and Latinos. The mechanisms underlying the increased risk for these populations should be further investigated.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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