Eight-hour time-restricted feeding improves endocrine and metabolic profiles in women with anovulatory polycystic ovary syndrome
Li C, Xing C, Zhang J, Zhao H, Shi W, He B
Journal of translational medicine · 128 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (81570765)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-04-13 · J Transl Med · vol. 19 · número 1 · pág. 148
- Editorial
- BioMed Central
- Citado
- 175 citas · más que el 99% de estudios similares · 13.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Ovarian function and disorders · Circadian rhythm and melatonin
- Palabras clave
- Polycystic ovary, Internal medicine, Endocrinology, Insulin resistance, Sex hormone-binding globulin, Medicine, Free androgen index, Anovulation, Luteinizing hormone, Body mass index, Type 2 diabetes, Metabolic syndrome, Insulin, Diabetes mellitus, Androgen, Hormone
- MeSH
- humans, polycystic ovary syndrome, anovulation, diabetes mellitus, type 2, insulin resistance, insulin, body mass index, fasting, adolescent, adult, female, metabolome, young adult
6 autores
- Chun‐Zhu Li🇨🇳China Medical University
- Chuan Xing🇨🇳China Medical University
- Jiaqi Zhang🇨🇳China Medical University
- Han Zhao🇨🇳China Medical University
- Wenjing Shi🇨🇳China Medical University
- Bing He🇨🇳 · autor de correspondenciaChina Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted feeding (TRF) is a form of intermittent fasting, which is beneficial for weight loss and cardiometabolic health. Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine and metabolic diseases affecting women of childbearing age. It is associated with an increased prevalence of metabolic syndrome, cardiovascular diseases and type 2 diabetes. The effects of TRF on PCOS patients remains undefined, here we investigated the impact of TRF on women with anovulatory PCOS.
Methods
Eighteen PCOS women aged between 18 and 31 with anovulation participated in a 6-week trial which were divided into two consecutive periods: (1) 1-week baseline weight stabilization period and (2) 5-week TRF period. Fifteen participants completed the study. Changes in body weight, body mass index (BMI), Waist-to-Hip Ratio, skeletal muscle mass, body fat mass (BFM), body fat percentage (BF%), visceral fat area (VFA), luteinizing hormone (LH), follicle-stimulating hormone (FSH), LH/FSH, total testosterone (TT), sex hormone-binding globulin (SHBG), free androgen index (FAI), fasting glucose, fasting insulin (FINS), homeostasis model assessment-insulin resistance (HOMA-IR), area under the curve (AUC) for insulin (AUCIns), area under the curve (AUC) for glucose (AUCGlu), AUCIns/AUCGlu Ratio, lipids, uric acid, alanine aminotransferase (ALT), aspartate aminotransferase, high-sensitivity C-reactive protein (hsCRP), insulin-like growth factor (IGF-1), menstrual cycle and eating behaviors were evaluated.
Results
Significant changes in body weight, BMI, BFM, BF%, VFA, TT, SHBG, FAI, FINS, HOMA-IR, AUCIns, AUCIns/AUCGlu Ratio, ALT, hsCRP and IGF-1 were found after the TRF period. An improvement in menstrual cycle irregularity was detected in 73.3% (11/15) patients.
Conclusion
The diet of TRF may be beneficial to anovulatory PCOS on weight loss especially reducing body fat, improving menstruation, hyperandrogenemia, insulin resistance and chronic inflammation. Trial registration Clinicaltrial.gov, NCT04580433, registered October 8, 2020, https://clinicaltrials.gov/ct2/show/NCT04580433.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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