A cream containing linoleic acid, 5% dexpanthenol and ceramide in the treatment of atopic dermatitis
Somjorn P, Kamanamool N, Kanokrungsee S, Rojhirunsakool S, Udompataikul M
Asian Pacific journal of allergy and immunology · 5 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-05-02 · Asian Pac J Allergy Immunol · vol. 42 · número 4 · págs. 361–367
- Citado
- 8 citas · más que el 74% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- Acceso abierto (publicación gratuita)
- Áreas de investigación
- Dermatology and Skin Diseases · Contact Dermatitis and Allergies · Neonatal skin health care
- Palabras clave
- atopic dermatitis, pediatric atopic dermatitis, emollients, linoleic acid, dexpanthenol, ceramide, urea cream, stratum corneum hydration, SCORAD, time to remission, topical treatment
- MeSH
- humans, dermatitis, atopic, ceramides, linoleic acid, pantothenic acid, emollients, treatment outcome, double-blind method, adolescent, child, child, preschool, female, male, skin cream
5 autores
- Phatthanan Somjorn🇹🇭Srinakharinwirot University
- Nanticha Kamanamool🇹🇭Srinakharinwirot University
- Silada Kanokrungsee🇹🇭Srinakharinwirot University
- Salinee Rojhirunsakool🇹🇭Srinakharinwirot University
- Montree Udompataikul🇹🇭Srinakharinwirot University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nowadays, moisturizers contain non-steroidal anti-inflammatory agents that help for treatment of atopic dermatitis (AD). Defensil® (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts, remain had a few studies for AD.
Objective
To compare the effectiveness of moisturizer containing 3% Defensil®, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in childhood AD treatment.
Methods
Thirty-eight patients with diagnosis of atopic dermatitis by UK working party's criteria were recruited in randomized, controlled, double-blinded 4-week study. The patients were received with twice-daily application of LDC cream on one side of the body and 5% urea cream on the opposite side. The clinical severity was assessed by modified scoring of atopic dermatitis (SCORAD). Median time to remission was analyzed by survival analysis.
Results
Thirty-seven out of 38 patients accomplished the protocol. The clinical SCORAD significantly improved from baseline in both groups (p < 0.001) after 2 and 4 weeks. Furthermore, the LDC group significantly reduced severity of disease better than the 5% urea group (P = 0.043). The mean difference SCORAD scores were -13.83 (±1.83) and -13.04 (±3.22) respectively. Stratum corneum hydration (SCH) was enhanced from baseline in both groups (p < 0.001) but no statistically significant difference between both groups. Median time to remission had no statistically significant difference (P = 0.697).
Conclusions
The effectiveness of LDC cream is better than 5% urea cream for improving clinical atopic dermatitis. It was suggested that moisturizer containing LDC could be used for the treatment of mild-to-moderate childhood atopic dermatitis.
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