The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial
Hemamy M, Pahlavani N, Amanollahi A, Islam SMS, McVicar J, Askari G, Malekahmadi M
BMC pediatrics · 40 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-04-17 · BMC Pediatr · vol. 21 · número 1 · pág. 178
- Editorial
- BioMed Central
- Citado
- 60 citas · más que el 96% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Attention Deficit Hyperactivity Disorder · Children's Physical and Motor Development · Bipolar Disorder and Treatment
- Palabras clave
- Medicine, Placebo, Randomized controlled trial, Vitamin D and neurology, Attention deficit hyperactivity disorder, Vitamin, Mental health, Internal medicine, Magnesium, Pediatrics, Psychiatry
- MeSH
- humans, magnesium, vitamin d, double-blind method, attention deficit disorder with hyperactivity, health status, dietary supplements, child
7 autores
- Mostafa Hemamy🇮🇷Isfahan University of Medical Sciences
- Naseh Pahlavani🇮🇷Kurdistan University of Medical Sciences; Gonabad University of Medical Sciences
- Alireza Amanollahi🇮🇷Shahid Beheshti University of Medical Sciences
- Sheikh Mohammed Shariful Islam🇦🇺Deakin University
- Jenna McVicar🇦🇺Deakin University
- Gholamreza Askari🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
- Mahsa Malekahmadi🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in people with ADHD. The aim of this study is to determine the effect of vitamin D and magnesium supplementation on mental health in children with ADHD.
Methods
We conducted a randomized, double blind, placebo-controlled clinical trial of 66 children with ADHD. Participants were randomly allocated to receive both vitamin D (50,000 IU/week) plus magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8-weeks. Strengths and difficulties questionnaire was used to evaluate children's mental health at baseline and the end of the study.
Results
After eight weeks of intervention, the serum levels of 25-hydroxy-vitamin D3 and magnesium increased significantly in the intervention group compared with the control group. Also, children receiving vitamin D plus magnesium showed a significant reduction in emotional problems (p = 0.001), conduct problems (p = 0.002), peer problems (p = 0.001), prosocial score (p = 0.007), total difficulties (p = 0.001), externalizing score (p = 0.001), and internalizing score (p = 0.001) compared with children treated with the placebo.
Conclusion
Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with ADHD. However, further well-designed studies with a larger sample size are needed.
Trial registration
IRCT2016030326886N1 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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