The effect of extra virgin olive oil on anthropometric indices, lipid profile, and markers of oxidative stress and inflammation in patients with depression, a double-blind randomised controlled trial
Foshati S, Ghanizadeh A, Akhlaghi M
International journal of clinical practice · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Shiraz University of Medical Sciences
- Universidad u hospital
- Shiraz University
- Subvenciones
- Shiraz University of Medical Sciences (94-01-87-10037)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-04-22 · Int J Clin Pract · vol. 75 · número 7 · pág. e14254
- Editorial
- Wiley
- Citado
- 11 citas · más que el 57% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Edible Oils Quality and Analysis · Fatty Acid Research and Health · Nutritional Studies and Diet
- Palabras clave
- extra virgin olive oil, depression, sunflower oil, anthropometric indices, waist circumference, body mass index, lipid profile, HDL cholesterol, malondialdehyde, oxidative stress, C-reactive protein, inflammation, obesity, overweight, cardiovascular risk factors
- MeSH
- humans, inflammation, lipids, double-blind method, depression, oxidative stress, female, male, olive oil
3 autores
- Sahar Foshati🇮🇷Shiraz University of Medical Sciences
- Ahmad Javid Ghanizadeh🇺🇸🇮🇷University of California, Los Angeles; Shiraz University of Medical Sciences; Kern Medical Center
- Masoumeh Akhlaghi🇮🇷 · autor de correspondenciaShiraz University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiological evidence suggests a mutual association between depression and obesity and also an anti-obesity effect for olive oil. We examined the effect of extra virgin olive oil (EVOO) on weight, waist circumference, and a number of cardiovascular risk factors in patients with depression.
Methods
The randomised double-blind controlled trial was conducted on 62 patients with depression. Patients were randomly allocated to EVOO and sunflower oil groups (n = 31 for each) that consumed 25 mL/day of the corresponding oils for 52 days. An isocaloric diet was prescribed to each patient according to his/her previous energy intake with considering the energy provided by the administered oils. Weight, body mass index (BMI), waist circumference, blood lipids, malondialdehyde, and hs-C reactive protein (CRP) analysis were performed using the intention-to-treat approach.
Results
BMI was significantly decreased in sunflower oil group (-0.20 ± 0.53 kg/m2 , P = .047) and waist circumference was significantly decreased in EVOO group (-2.15 ± 2.09 cm, P < .001); however, only reduction of waist circumference was significantly different between groups (P < .001). High-density lipoprotein (HDL) cholesterol was significantly increased in EVOO group (3.02 ± 6.79 mg/dL, P = .03), without showing a significant between-group difference. Other lipids, malondialdehyde, and hs-CRP did not change.
Conclusion
Overall, the results suggest that both EVOO and sunflower oil may benefit overweight patients with depression, as they respectively decreased waist circumference and BMI without need for administration of a low-calorie diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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