Low-level laser or LED photobiomodulation on oral mucositis in pediatric patients under high doses of methotrexate: prospective, randomized, controlled trial
Guimaraes DM, Ota TMN, Da Silva DAC, Almeida FLDS, Schalch TD, Deana AM, Junior JMA, Fernandes KPS
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 24 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-04-24 · Support Care Cancer · vol. 29 · número 11 · págs. 6441–6447
- Editorial
- Springer Science+Business Media
- Citado
- 32 citas · más que el 93% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, light-emitting diode therapy, oral mucositis, childhood acute lymphoblastic leukemia, methotrexate, oral pain, mucositis prevention
- MeSH
- humans, stomatitis, methotrexate, prospective studies, lasers, child, mucositis, low-level light therapy
8 autores
- Douglas Magno Guimarães🇧🇷 · autor de correspondenciaUniversidade Nove de Julho
- Tâmara Melo Nunes Ota
- Diego Assunção Calixto da Silva
- Fabio De Lucas Da Silva Almeida
- Tatiana Dias Schalch🇧🇷Universidade Nove de Julho
- Alessandro Melo Deana🇧🇷Universidade Nove de Julho
- Jose Miguel Alves
- Kristianne Porta Santos Fernandes🇧🇷Universidade Nove de Julho
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The objective of the present study was to compare the efficacy of photobiomodulation with low-level laser therapy (LLLT) or light-emitting diode therapy (LEDT) devices for the prevention and treatment of oral mucositis in pediatric patients diagnosed with acute lymphoblastic leukemia undergoing chemotherapy with high doses of methotrexate (MTX).
Methods
Eighty patients were randomly divided into two groups: LLLT and LEDT. Both protocols were applied with the same energy and radiant exposure. The protocols started in the beginning of high doses MTX and finished when the patients were discharged from the hospital or there was oral mucositis resolution. The oral mucositis was assessed during each session in accordance to the World Health Organization (WHO) score. The patients' self-assessed pain was scored on a visual analog scale (VAS).
Results
The incidence of oral mucositis was similar to LLLT and LEDT, 10% and 12.5%, respectively. Both groups required the same number of days to reach score of zero for mucositis and pain (p > 0. 05), and there was no significant difference in mean VAS between the groups.
Conclusions
These findings suggest that LEDT has similar effects to LLLT to avoid and treat oral mucositis. Brazilian Clinical Trial Registry with #U1111-1221-5943.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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