Intraoral versus extraoral photobiomodulation therapy in the prevention of oral mucositis in HSCT patients: a randomized, single-blind, controlled clinical trial
Ramos-Pinto MB, de Lima Gusmão TP, Schmidt-Filho J, Jaguar GC, Martins MD, Alves FA
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 17 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-04-27 · Support Care Cancer · vol. 29 · número 11 · págs. 6495–6503
- Editorial
- Springer Science+Business Media
- Citado
- 24 citas · más que el 88% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, hematopoietic stem cell transplantation, mucositis prevention, myeloablative conditioning, autologous transplantation, buccal mucosa
- MeSH
- humans, stomatitis, transplantation conditioning, hematopoietic stem cell transplantation, single-blind method, low-level light therapy
6 autores
- Mariana Bitu Ramos-Pinto🇧🇷AC Camargo Hospital
- TERESA PAULA DE LIMA GUSMÃO🇧🇷AC Camargo Hospital
- Jayr Schmidt-Filho🇧🇷AC Camargo Hospital
- Graziella Chagas Jaguar🇧🇷AC Camargo Hospital
- Manoela Domingues Martins🇧🇷Universidade Federal do Rio Grande do Sul
- Fábio Abreu Alves🇧🇷 · autor de correspondenciaUniversidade de São Paulo; AC Camargo Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
To compare the efficacy of intraoral and extraoral photobiomodulation (PBM) protocols for the prevention of oral mucositis (OM) in hematopoietic stem cell transplantation (HSCT) patients. A total of 60 patients was randomized into intraoral PBM (IOPBM) and extraoral PBM (EOPBM) groups. Both PBM protocols were well tolerated and no side effects were observed. EOPBM session times were one fourth of IOPBM durations. Of 60 patients, 35 (58.3%) developed ulcerated OM between day +3 and day +12. No intergroup difference was observed in OM healing times (p = 0.424). The lateral border of the tongue was the most common site affected in both groups. However, the incidence of mucositis on buccal mucosa was significantly reduced in the EOPBM group (p = 0.021). Young patients (OR.5.35, 95%CI 0.94-30.4, p = 0.058) and those who had received myeloablative conditioning (OR.55.1, 95%CI 2.69-1129.3, p = 0.009) were more likely to develop ulcerated OM, whereas autologous HSCT recipients (OR 0.079, 95% CI 0.009-0.67, p = 0.021) had a lower probability of developing ulcerated OM independent of PBM protocol. EOPBM protocol was as effective as IOPBM in the management of OM in HSCT patients, with the advantage of shorter treatment sessions. Trial registration number: RBR-7nww56. Date of trial registration submission: 30th September 2019.
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