The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis
Yusin J, Wang V, Henning SM, Yang J, Tseng CH, Thames G, Arnold I, Heber D, Lee RP, Sanavio L, Pan Y, Qin T, Li Z
Nutrients · 11 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Research and Development
- Subvenciones
- Office of Research and Development (2019-070565)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-04-17 · Nutrients · vol. 13 · número 4 · pág. 1337
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 12 citas · más que el 74% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Allergic Rhinitis and Sensitization · Asthma and respiratory diseases · Sinusitis and nasal conditions
- Palabras clave
- broccoli sprout extract, allergic rhinitis, grass pollen allergy, dietary supplementation, intranasal corticosteroids, peak nasal inspiratory flow, Total Nasal Symptom Score, antioxidant therapy, nasal challenge
- MeSH
- nasal mucosa, humans, brassica, poaceae, pollen, adrenal cortex hormones, plant extracts, allergens, cytokines, treatment outcome, drug therapy, combination, administration, intranasal, double-blind method, adult, aged, middle aged, female, rhinitis, allergic, seasonal, male, nasal sprays
13 autores
- Joseph Stephen Yusin🇺🇸 · autor de correspondenciaVA Greater Los Angeles Healthcare System
- Vivian Ying Wang🇺🇸VA Greater Los Angeles Healthcare System
- Susanne M. Henning🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Jieping Yang🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Chi‐Hong Tseng🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Gail Thames🇺🇸University of California, Los Angeles; Los Angeles Medical Center; VA Greater Los Angeles Healthcare System
- Irina Y. Arnold🇺🇸University of California, Los Angeles; Los Angeles Medical Center; VA Greater Los Angeles Healthcare System
- David Heber🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Ru‐Po Lee🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Laura Sanavio🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Yajing Pan🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Tianyu Qin🇺🇸University of California, Los Angeles; Los Angeles Medical Center
- Zhaoping Li🇺🇸University of California, Los Angeles; Los Angeles Medical Center; VA Greater Los Angeles Healthcare System
Resumen
El texto original del estudio, en el idioma en que se publicó.
Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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