Egg consumption, overall diet quality, and risk of type 2 diabetes and coronary heart disease: A pooling project of US prospective cohorts

Djoussé L, Zhou G, McClelland RL, Ma N, Zhou X, Kabagambe EK, Talegawkar SA, Judd SE, Biggs ML, Fitzpatrick AL, Clark CR, Gagnon DR, Steffen LM, Gaziano JM, Lee IM, Buring JE, Manson JE

Clinical nutrition (Edinburgh, Scotland) · 15 citas

Etiquetas de revisión

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Cómo se estudió

Diseño: Metaanálisis (indexado por PubMed)
Estudiado en: Personas
Resultado principal: Eventos clínicos como enfermedad o muerte
Consumo medido con: No se indica

Quién lo pagó

Financiación: Financiado por la industria
Grupo de la industria: Egg Nutrition Center
Gobierno: National Institutes of Health
Gobierno: National Institute on Aging
Gobierno: National Heart, Lung, and Blood Institute
Gobierno: National Cancer Institute
Gobierno: National Institute of Diabetes and Digestive and Kidney Diseases
Gobierno: National Institute of Neurological Disorders and Stroke
Gobierno: National Center for Advancing Translational Sciences
Gobierno: National Institute on Minority Health and Health Disparities
Gobierno: NHLBI NIH HHS
Gobierno: NIMHD NIH HHS
Gobierno: NINDS NIH HHS
Gobierno: NCI NIH HHS
Gobierno: NCATS NIH HHS
Gobierno: NIDDK NIH HHS
Gobierno: NIA NIH HHS
Subvenciones: National Heart, Lung, and Blood Institute (HHSN268201700004I); National Heart, Lung, and Blood Institute (N01 HC085086); National Heart, Lung, and Blood Institute (N01-HC095169); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079626); National Heart, Lung, and Blood Institute (N01-HC-095165); National Heart, Lung, and Blood Institute (R21HL088081); National Heart, Lung, and Blood Institute (HHSN268201800004I); National Heart, Lung, and Blood Institute (N01 HC085079); National Heart, Lung, and Blood Institute (N01 HC095163); National Heart, Lung, and Blood Institute (R01‐HL043851); National Heart, Lung, and Blood Institute (HHSN268201800012C); National Heart, Lung, and Blood Institute (N01 HC085083); National Heart, Lung, and Blood Institute (HHSN268201800010 I); National Institute on Aging (R01 AG 023629); National Heart, Lung, and Blood Institute (HHSN268201800014 I); National Heart, Lung, and Blood Institute (N01 HC085080); National Heart, Lung, and Blood Institute (HHSN 268200800007C); National Heart, Lung, and Blood Institute (HHSN268201800001C); National Heart, Lung, and Blood Institute (R01 HL080467); National Heart, Lung, and Blood Institute (HHSN268201800012 I); National Heart, Lung, and Blood Institute (U01HL130114); National Heart, Lung, and Blood Institute (N01-HC-095159); National Heart, Lung, and Blood Institute (N01 HC095168); National Heart, Lung, and Blood Institute (HHSN268201800005I); National Heart, Lung, and Blood Institute (HHSN268201700001I); National Heart, Lung, and Blood Institute (N01-HC-095162); National Heart, Lung, and Blood Institute (N01-HC-095161); National Cancer Institute (R01 CA034944); National Heart, Lung, and Blood Institute (HHSN268201100011I); National Heart, Lung, and Blood Institute (R01 HL026490); National Heart, Lung, and Blood Institute (HHSN268201800014C); National Heart, Lung, and Blood Institute (HHSN268201700005C); National Heart, Lung, and Blood Institute (HHSN268201700003I); National Cancer Institute (HHSN261201800014I); National Heart, Lung, and Blood Institute (HHSN268201500003C); National Heart, Lung, and Blood Institute (HHSN26820150 0003I); National Cancer Institute (U01 CA182913); National Cancer Institute (R01CA097193); National Heart, Lung, and Blood Institute (HHSN268201200036C); National Heart, Lung, and Blood Institute (HHSN268201700005I); National Heart, Lung, and Blood Institute (N01 HC095167); National Heart, Lung, and Blood Institute (HHSN268201800015I); National Heart, Lung, and Blood Institute (N01HC085082); National Heart, Lung, and Blood Institute (RC1HL099355); National Heart, Lung, and Blood Institute (HHSN268201700001C); National Heart, Lung, and Blood Institute (U01HL080295); National Heart, Lung, and Blood Institute (N01-HC-095160); National Heart, Lung, and Blood Institute (HHSN268201800006I); National Heart, Lung, and Blood Institute (N01 HC055222); National Heart, Lung, and Blood Institute (N01 HC095166); National Institutes of Health (UL1TR001079); National Heart, Lung, and Blood Institute (R01HL034595); National Heart, Lung, and Blood Institute (N01 HC095164); National Heart, Lung, and Blood Institute (HHSN268201700002I); National Cancer Institute (HHSN261201800012I); National Heart, Lung, and Blood Institute (HHSN268201800011C); National Heart, Lung, and Blood Institute (HHSN268201800011I); National Heart, Lung, and Blood Institute (HHSN268201700003C); National Heart, Lung, and Blood Institute (N01 HC085081); National Heart, Lung, and Blood Institute (HHSN268201700002C); National Cancer Institute (R01CA047988); National Institutes of Health (UL1TR000040); National Cancer Institute (UM1 CA182913); National Heart, Lung, and Blood Institute (HHSN268201800007I); National Heart, Lung, and Blood Institute (HHSN268201800003I); National Cancer Institute (R01 CA040360); National Cancer Institute (HHSN261201800010I); National Heart, Lung, and Blood Institute (HHSN268201700004C); National Institute on Minority Health and Health Disparities (HHSN268201800013I); National Institute of Neurological Disorders and Stroke (U01 NS041588)); National Center for Advancing Translational Sciences (UL1TR001420)

Según 16 financiadores declarados.

Publicación

Publicado: 2021-03-12 · Clin Nutr · vol. 40 · número 5 · págs. 2475–2482
Editorial: Elsevier BV
Citado: 23 citas · más que el 93% de estudios similares · 3.7× el promedio de su campo
Impacto: Entre el 10 % más citado de su campo
Referencias: 52 trabajos
Acceso: Acceso abierto (copia en repositorio)
Áreas de investigación: Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins · Food composition and properties
Palabras clave: egg consumption, type 2 diabetes, coronary artery disease, dietary habits, diet quality, dietary confounding, older adults, body mass index, pooled cohort analysis
MeSH: humans, coronary disease, diabetes mellitus, type 2, diet, risk factors, cohort studies, prospective studies, eggs, adult, aged, middle aged, united states

DOI ↗PubMed Central ↗OpenAlex ↗

17 autores

Luc Djoussé🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University; VA Boston Healthcare System
Guohai Zhou🇺🇸Brigham and Women's Hospital
Robyn L. McClelland🇺🇸University of Washington
Nanxun Ma🇺🇸University of Washington
Xia Zhou🇺🇸University of Minnesota
Edmond Kato Kabagambe🇺🇸Ochsner Health System
Sameera A. Talegawkar🇺🇸George Washington University
Suzanne E. Judd🇺🇸University of Alabama at Birmingham
Mary L. Biggs🇺🇸University of Washington
Annette L. Fitzpatrick🇺🇸University of Washington
Cheryl R. Clark🇺🇸Brigham and Women's Hospital; Harvard University
DAVID R. GAGNON🇺🇸Boston University; VA Boston Healthcare System
Lyn M. Steffen🇺🇸University of Minnesota
J. Michael Gaziano🇺🇸Brigham and Women's Hospital; Harvard University; VA Boston Healthcare System
I‐Min Lee🇺🇸Brigham and Women's Hospital; Harvard University
Julie E. Buring🇺🇸Brigham and Women's Hospital; Harvard University
JoAnn E. Manson🇺🇸Brigham and Women's Hospital; Harvard University

Resumen

El texto original del estudio, en el idioma en que se publicó.

Background and aims

Data on the relation of egg consumption with risk of type 2 diabetes (T2D) and coronary heart disease (CHD) are limited and inconsistent. Few studies have controlled for overall dietary patterns in egg-T2D or egg-CHD analyses, and it is unclear whether any observed elevated risks of T2D and CHD with frequent egg consumption is real or due to confounding by dietary habits. We tested the hypothesis that frequent egg consumption is associated with a higher risk of T2D and CHD risk after adjustment for overall dietary patterns among adults.

Design

We used prospective cohort design to complete time-to-event analyses.

Methods

We pooled de novo, harmonized, individual-level analyses from nine US cohorts (n = 103,811). Cox regression was used to estimate hazard ratios separately in each cohort adjusting for age, ethnicity, body mass index (BMI), exercise, smoking, alcohol intake, and dietary patterns. We pooled cohort-specific results using an inverse-variance weighted method to estimate summary relative risks.

Results

Median age ranged from 25 to 72 years. Median egg consumption was 1 egg per week in most of the cohorts. While egg consumption up to one per week was not associated with T2D risk, consumption of ≥2 eggs per week was associated with elevated risk [27% elevated risk of T2D comparing 7+ eggs/week with none (95% CI: 16%-37%)]. There was little evidence for heterogeneity across cohorts and we observed similar conclusions when stratified by BMI. Overall, egg consumption was not associated with the risk of CHD. However, in a sensitivity analysis, there was a 30% higher risk of CHD (95% CI: 3%-56%) restricted to older adults consuming 5-6 eggs/week.

Conclusions

Our data showed an elevated risk of T2D with egg consumption of ≥2 eggs per week but not with <2 eggs/week. While there was no overall association of egg consumption with CHD risk, the elevated CHD observed with consumption of 5-6 eggs/week in older cohorts merits further investigation.

Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.

Leer el texto completo ↗Ver en PubMed ↗

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