Photobiomodulation Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies
Salehpour F, Khademi M, Hamblin MR
Journal of Alzheimer's disease : JAD · 41 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- NIAID NIH HHS
- Subvenciones
- National Institute of Allergy and Infectious Diseases (R21 AI121700); National Institute of Allergy and Infectious Diseases (R01AI050875)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-04-30 · J Alzheimers Dis · vol. 83 · número 4 · págs. 1431–1452
- Editorial
- IOS Press
- Citado
- 46 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 116 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Optical Imaging and Spectroscopy Techniques
- Palabras clave
- low-level laser therapy, dementia
- MeSH
- animals, humans, dementia, models, animal, clinical studies as topic, low-level light therapy
3 autores
- Farzad Salehpour · autor de correspondencia
- Mahsa Khademi🇮🇷Tabriz University of Medical Sciences
- Michael R. Hamblin🇿🇦 · autor de correspondenciaUniversity of Johannesburg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Photobiomodulation (PBM) involves the use of red and/or near-infrared light from lasers or LEDs to improve a wide range of medical disorders. Transcranial PBM, sometimes accompanied by intranasal PBM, has been tested to improve many brain disorders, including dementia.
Objective
To conduct a systematic review according to PRISMA guidelines of pre-clinical and clinical studies reporting the use of PBM, which were considered relevant to dementia.
Methods
Literature was searched between 1967 and 2020 using a range of keywords relevant to PBM and dementia. The light source and wavelength(s), output power, irradiance, irradiation time, fluence or total energy (dose), operation mode (continuous or pulsed) irradiation, approach and site, number of treatment sessions, as well as study outcome(s) were extracted.
Results
Out of 10,473 initial articles, 36 studies met the inclusion criteria. Nine articles reported in vitro studies, 17 articles reported studies in animal models of dementia, and 10 studies were conducted in dementia patients. All of the included studies reported positive results. The clinical studies were limited by the small number of patients, lack of placebo controls in some instances, and only a few used objective neuroimaging methods.
Conclusion
The preliminary evidence of clinical benefit, the lack of any adverse effects, and the remarkable ease of use, suggest larger clinical trials should be conducted as soon as possible.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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