Genetically determined variations of selenoprotein P are associated with antioxidant, muscular, and lipid biomarkers in response to Brazil nut consumption by patients using statins
Moriguchi Watanabe L, Bueno AC, de Lima LF, Ferraz-Bannitz R, Dessordi R, Guimarães MP, Foss-Freitas MC, Barbosa F, Navarro AM
The British journal of nutrition · 11 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidade de São Paulo
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-05-05 · Br J Nutr · vol. 127 · número 5 · págs. 679–686
- Editorial
- Cambridge University Press
- Citado
- 30 citas · más que el 94% de estudios similares · 3.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Selenium in Biological Systems · Trace Elements in Health · Vitamin D Research Studies
- Palabras clave
- GPX1, Brazil nut, Single-nucleotide polymorphism, Selenoprotein, Glutathione peroxidase, Selenoprotein P, Biology, Internal medicine, Vitamin E, Endocrinology, Genotype, Antioxidant, Medicine, Genetics, Oxidative stress, Biochemistry, Superoxide dismutase, Gene, Food science
- MeSH
- humans, bertholletia, selenium, glutathione peroxidase, triglycerides, rna, messenger, hydroxymethylglutaryl-coa reductase inhibitors, antioxidants, selenoproteins, selenoprotein p, biomarkers
9 autores
- Lígia Moriguchi Watanabe🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Ana Carolina Bueno🇧🇷Universidade de São Paulo
- Lívia Fernandes de Lima🇧🇷Universidade de São Paulo
- Rafael Ferraz Bannitz🇧🇷Universidade de São Paulo
- Renata Dessordi🇧🇷Universidade Estadual Paulista (Unesp)
- Mariana P. Guimarães🇧🇷Universidade de São Paulo
- Maria Cristina Foss‐Freitas🇧🇷Universidade de São Paulo
- Fernando Barbosa🇧🇷Universidade de Ribeirão Preto; Universidade de São Paulo
- Anderson Marliere Navarro🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Several single nucleotide polymorphisms (SNPs) could indirectly, as well directly, influence metabolic parameters related to health effects in response to selenium (Se) supplementation. This study aimed to investigate whether the selenoprotein SNPs were associated with the response of Se status biomarkers to the Brazil nut consumption in patients using statins and if the variation in Se homoeostasis could affect antioxidant protection, lipid profile, muscle homoeostasis and selenoproteins mRNA. The study was performed in the Ribeirão Preto Medical School University Hospital. Thirty-two patients using statins received one unit of Brazil nut daily for 3 months. Body composition, blood Se concentrations, erythrocyte glutathione peroxidase (GPX) activity, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triacylglycerol (TAG), creatine kinase (CK) activity and gene expression of GPX1 and selenoprotein P (SELENOP) were evaluated before and after Brazil nut consumption. The volunteers were genotyped for SNP in GPX1 (rs1050450) and SELENOP (rs3877899 and rs7579). SNPs in selenoproteins were not associated with plasma and erythrocyte Se, but SNPs in SELENOP influenced the response of erythrocyte GPX activity and CK activity, TAG and LDL after Brazil nut consumption. Also, Brazil nut consumption increased GPX1 mRNA expression only in subjects with rs1050450 CC genotype. SELENOP mRNA expression was significantly lower in subjects with rs7579 GG genotype before and after the intervention. Thus, SNP in SELENOP could be associated with interindividual differences in Se homeostasis after Brazil nut consumption, emphasising the involvement of genetic variability in response to Se consumption towards health maintenance and disease prevention.
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