The relationship between the severity and mortality of SARS-CoV-2 infection and 25-hydroxyvitamin D concentration - a metaanalysis
Oscanoa TJ, Amado J, Vidal X, Laird E, Ghashut RA, Romero-Ortuno R
Advances in respiratory medicine · 34 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-04-22 · Adv Respir Med · vol. 89 · número 2 · págs. 145–157
- Citado
- 46 citas · más que el 97% de estudios similares · 5.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Biotin and Related Studies
- Palabras clave
- Medicine, Vitamin D and neurology, Internal medicine, vitamin D deficiency, Cochrane Library, Relative risk, Coronavirus disease 2019 (COVID-19), Hypovitaminosis, Epiphenomenon, Randomized controlled trial, Gastroenterology, Disease, Confidence interval, Infectious disease (medical specialty)
- MeSH
- humans, vitamin d deficiency, vitamin d, severity of illness index, age factors, female, male, covid-19
6 autores
- Teodoro J. Oscanoa🇵🇪 · autor de correspondenciaNational University of San Marcos; Universidad de San Martín de Porres
- José Amado🇵🇪National University of San Marcos; Universidad de San Martín de Porres
- Xavier Vidal🇪🇸Vall d'Hebron Hospital Universitari
- Eamon J. Laird🇮🇪Trinity College Dublin
- Rawia A. Ghashut🇬🇧Glasgow Royal Infirmary; University of Glasgow
- Román Romero‐Ortuño🇮🇪Trinity College Dublin; St. James's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
There is increasing scientific interest in the possible association between hypovitaminosis D and the risk of SARS-CoV-2 infection severity and/or mortality.
Objective
To conduct a metanalysis of the association between 25-hydroxyvitamin D (25(OH)D) concentration and SARS-CoV-2 infection severity or mortality.
Material and methods
We searched PubMed, EMBASE, Google scholar and the Cochrane Database of Systematic Reviews for studies published between December 2019 and December 2020. Effect statistics were pooled using random effects models. The quality of included studies was assessed with the Newcastle-Ottawa Scale (NOS). Targeted outcomes: mortality and severity proportions in COVID-19 patients with 25(OH)D deficiency, defined as serum 25(OH)D < 50 nmol/L.
Results
In the 23 studies included (n = 2692), the mean age was 60.8 (SD ± 15.9) years and 53.8% were men. Results suggested that vitamin 25(OH)D deficiency was associated with increased risk of severe SARS-CoV-2 disease (RR 2.00; 95% CI 1.47-2.71, 17 studies) and mortality (RR 2.45; 95% CI 1.24-4.84, 13 studies). Only 7/23 studies reported C-reactive protein values, all of which were > 10 mg/L. Conclusions 25(OH)D deficiency seems associated with increased SARS-CoV-2 infection severity and mortality. However, findings do not imply causality, and randomized controlled trials are required, and new studies should be designed to determine if decreased 25(OH)D is an epiphenomenon or consequence of the inflammatory process associated with severe forms of SARS-CoV-2. Meanwhile, the concentration of 25(OH)D could be considered as a negative acute phase reactant and a poor prognosis in COVID-19 infection.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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