Oral chronic sulforaphane effects on heavy resistance exercise: Implications for inflammatory and muscle damage parameters in young practitioners
Sato K, Kihara H, Kumazawa Y, Tatara K
Nutrition (Burbank, Los Angeles County, Calif.) · 17 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- TOBE MAKI Scholarship Foundation
- Gobierno
- Japan Society for the Promotion of Science
- Organización sin fines de lucro
- Tobe Maki Scholarship Foundation
- Subvenciones
- Japan Society for the Promotion of Science (19H01755)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2021-04-07 · Nutrition · vol. 90 · pág. 111266
- Editorial
- Elsevier BV
- Citado
- 26 citas · más que el 87% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- sulforaphane, broccoli sprouts, resistance training, exercise-induced muscle damage, creatine kinase, interleukin-6, inflammatory cytokines, dietary supplementation, phytochemicals, athletes
- MeSH
- muscles, muscle, skeletal, humans, isothiocyanates, sulfoxides, exercise, double-blind method, dietary supplements, adult, male, resistance training, young adult
4 autores
- Koji Sato🇯🇵 · autor de correspondenciaKobe University
- Hinata Kihara🇯🇵Kobe University
- Yoka Kumazawa🇯🇵Kobe University
- Koki Tatara🇯🇵Kobe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Sulforaphane is a phytochemical that is commonly found in broccoli and broccoli sprouts. However, whether chronic sulforaphane ingestion suppresses heavy resistance exercise-induced muscle damage parameters in humans remains unknown. Therefore, this study investigated the effects of oral chronic sulforaphane ingestion on heavy resistance exercise-induced muscle damage parameters.
Methods
The study had a randomized, double-blind, placebo-controlled, cross-over design. Ten healthy young men (age: 22.0 ± 0.3 y; body weight: 62.6 ± 2.4 kg; height: 171.0 ± 0.1 cm) were administered placebo or sulforaphane (30 mg/d) for 4 wk at the first trial, then after a 4-wk washout period, the participants were administered the opposite treatment for 4 wk at the second trial. The participants were subjected to heavy resistance exercise (bench press, 85% of one-repetition maximum for three times with eight repetitions) after each administration, and blood samples were collected before and at 30 min and 24 h after each exercise session.
Results
In this study, 4 wk of sulforaphane intake decreased plasma levels of creatine kinase, especially creatine kinase levels from 30 min to 24 h and baseline to 24 h. Moreover, the change in interleukin-6 levels significantly decreased from baseline to 30 min on prolonged intake of sulforaphane.
Conclusions
Together, these findings suggest that the oral chronic intake of sulforaphane suppressed the heavy resistance exercise-induced increase in muscle damage parameter and expression of inflammatory cytokines. The chronic use of sulforaphane may be a novel therapeutic candidate for the prevention of muscle damage in athletes training daily with high-intensity exercise.
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