Effects of Melatonin and/or Magnesium Supplementation on Biomarkers of Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
Mousavi R, Alizadeh M, Asghari Jafarabadi M, Heidari L, Nikbakht R, Babaahmadi Rezaei H, Karandish M
Biological trace element research · 43 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Tabriz University of Medical Sciences
- Universidad u hospital
- Ahvaz Jundishapur University of Medical Sciences
- Subvenciones
- Tabriz University of Medical Sciences (64999); Ahvaz Jundishapur University of Medical Sciences (NRC-9815)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-05-19 · Biol Trace Elem Res · vol. 200 · número 3 · págs. 1010–1019
- Editorial
- Springer Science+Business Media
- Citado
- 108 citas · más que el 100% de estudios similares · 163.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ovarian function and disorders · Magnesium in Health and Disease · Circadian rhythm and melatonin
- Palabras clave
- polycystic ovary syndrome, melatonin supplementation, magnesium supplementation, combination supplementation, inflammatory markers, oxidative stress, TNF-α, total antioxidant capacity, hirsutism, waist circumference, women
- MeSH
- humans, polycystic ovary syndrome, inflammation, magnesium, melatonin, double-blind method, oxidative stress, dietary supplements, adolescent, adult, female, young adult, biomarkers
7 autores
- Reihaneh Mousavi🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Mohammad Alizadeh🇮🇷Tabriz University of Medical Sciences
- Mohammad Asghari Jafarabadi🇮🇷Zanjan University of Medical Sciences; Tabriz University of Medical Sciences
- Lida Heidari
- Roshan Nikbakht🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Hossein Babaahmadi‐Rezaei🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Majid Karandish🇮🇷 · autor de correspondenciaAhvaz Jundishapur University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium and melatonin are known to exert multiple beneficial effects including anti-inflammatory and antioxidant actions. This study was designed to determine the effects of magnesium and/or melatonin supplementation on metabolic profiles in women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was conducted among 84 subjects with PCOS aged 18-40 years old. Patients were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, or placebo for 8 weeks. Fasting blood samples were taken at baseline and after the intervention to quantify related variables. After the 8-week intervention, an insignificant marginal difference was seen in waist circumference (WC) between groups (P = 0.085). Magnesium-melatonin co-supplementation resulted in more reductions in hirsutism compared with other groups (P < 0.001). Serum levels of tumor necrosis factor-α (TNF-α) declined significantly in the melatonin and co-supplementation groups compared to baseline (P < 0.05). Also, magnesium plus melatonin was associated with a more increase in total antioxidant capacity (TAC) levels, as compared to the other treatment groups (P = 0.001). Overall, we found a favorable effect of co-supplementation of magnesium and melatonin for 8 weeks in women with PCOS on hirsutism, serum TNF-α, and TAC levels. Furthermore, melatonin independently contributed to decreased serum values of TNF-α.Clinical trial registration number http://www.irct.ir : IRCT20191130045556N1, January 2020.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.