Regular Caffeine Intake Delays REM Sleep Promotion and Attenuates Sleep Quality in Healthy Men
Weibel J, Lin YS, Landolt HP, Berthomier C, Brandewinder M, Kistler J, Rehm S, Rentsch KM, Meyer M, Borgwardt S, Cajochen C, Reichert CF
Journal of biological rhythms · 31 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Organización sin fines de lucro
- Janggen-Pöhn-Stiftung
- Organización sin fines de lucro
- Mathieu-Stiftung
- Gobierno
- Swiss National Science Foundation
- Organización sin fines de lucro
- Nikolaus und Bertha Burckhardt-Bürgin-Stiftung
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (163058); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (320030)
Según 6 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-05-23 · J Biol Rhythms · vol. 36 · número 4 · págs. 384–394
- Editorial
- SAGE Publishing
- Citado
- 40 citas · más que el 90% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Sleep and Wakefulness Research · Coffee research and impacts · Sleep and related disorders
- Palabras clave
- caffeine, REM sleep, circadian rhythm, sleep quality, sleep pressure, caffeine withdrawal, REM latency, sleep architecture, sleep-wake cycle
- MeSH
- humans, caffeine, electroencephalography, cross-over studies, sleep, sleep, rem, circadian rhythm, child, preschool, male
12 autores
- Janine Weibel🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Yu-Shiuan Lin🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Hans‐Peter Landolt🇨🇭University of Zurich
- Christian Berthomier
- Marie Brandewinder
- Joshua Kistler🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Sophia Rehm🇨🇭University of Basel; University Hospital of Basel
- Katharina Rentsch🇨🇭University of Basel; University Hospital of Basel
- Martin Meyer🇨🇭University of Basel; University Hospital of Basel; Universitäre Psychiatrische Kliniken Basel
- Stefan Borgwardt🇨🇭University of Basel; Universitäre Psychiatrische Kliniken Basel
- Christian Cajochen🇨🇭 · autor de correspondenciaUniversity of Basel; University Hospital of Basel; Universitäre Psychiatrische Kliniken Basel
- Carolin Reichert🇨🇭University of Basel; University Hospital of Basel; Universitäre Psychiatrische Kliniken Basel
Resumen
El texto original del estudio, en el idioma en que se publicó.
Acute caffeine intake can attenuate homeostatic sleep pressure and worsen sleep quality. Caffeine intake-particularly in high doses and close to bedtime-may also affect circadian-regulated rapid eye movement (REM) sleep promotion, an important determinant of subjective sleep quality. However, it is not known whether such changes persist under chronic caffeine consumption during daytime. Twenty male caffeine consumers (26.4 ± 4 years old, habitual caffeine intake 478.1 ± 102.8 mg/day) participated in a double-blind crossover study. Each volunteer completed a caffeine (3 × 150 mg caffeine daily for 10 days), a withdrawal (3 × 150 mg caffeine for 8 days then placebo), and a placebo condition. After 10 days of controlled intake and a fixed sleep-wake cycle, we recorded electroencephalography for 8 h starting 5 h after habitual bedtime (i.e., start on average at 04:22 h which is around the peak of circadian REM sleep promotion). A 60-min evening nap preceded each sleep episode and reduced high sleep pressure levels. While total sleep time and sleep architecture did not significantly differ between the three conditions, REM sleep latency was longer after daily caffeine intake compared with both placebo and withdrawal. Moreover, the accumulation of REM sleep proportion was delayed, and volunteers reported more difficulties with awakening after sleep and feeling more tired upon wake-up in the caffeine condition compared with placebo. Our data indicate that besides acute intake, also regular daytime caffeine intake affects REM sleep regulation in men, such that it delays circadian REM sleep promotion when compared with placebo. Moreover, the observed caffeine-induced deterioration in the quality of awakening may suggest a potential motive to reinstate caffeine intake after sleep.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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