Marching to the Beet: The effect of dietary nitrate supplementation on high altitude exercise performance and adaptation during a military trekking expedition
Marshall AR, Rimmer JE, Shah N, Bye K, Kipps C, Woods DR, O'Hara J, Boos CJ, Barlow M
Nitric oxide : biology and chemistry · 10 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Leeds Beckett University
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-05-27 · Nitric Oxide · vol. 113-114 · págs. 70–77
- Editorial
- Elsevier BV
- Citado
- 13 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- De pago
- Áreas de investigación
- High Altitude and Hypoxia · Exercise and Physiological Responses · Cardiovascular and exercise physiology
- Palabras clave
- nitrate supplementation, beetroot juice, high altitude, hypobaric hypoxia, exercise performance, salivary nitrite, altitude sickness, peripheral oxygen saturation, heart rate recovery, physical fitness decline
- MeSH
- humans, nitrates, nitrites, exercise, altitude, adaptation, physiological, dietary supplements, adult, military personnel, female, male, fruit and vegetable juices, hypoxia
9 autores
- Anna Marshall🇬🇧 · autor de correspondenciaUniversity College London
- Joanna E. Rimmer
- Nishma Shah🇬🇧University College London
- Kyo Bye
- Courtney Kipps🇬🇧University College London
- David Richard Woods🇬🇧Royal Victoria Infirmary; Leeds Beckett University
- John Paul O'Hara🇬🇧Leeds Beckett University
- Christopher John Boos🇬🇧Poole Hospital NHS Foundation Trust; Leeds Beckett University; Bournemouth University
- Matthew Barlow🇬🇧Leeds Beckett University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The aim was to investigate the effect of dietary nitrate supplementation (in the form of beetroot juice, BRJ) for 20 days on salivary nitrite (a potential precursor of bioactive nitric oxide), exercise performance and high altitude (HA) acclimatisation in field conditions (hypobaric hypoxia).
Methods
This was a single-blinded randomised control study of 22 healthy adult participants (12 men, 10 women, mean age 28 ± 12 years) across a HA military expedition. Participants were randomised pre-ascent to receive two 70 ml dose per day of either BRJ (~12.5 mmol nitrate per day; n = 11) or non-nitrate calorie matched control (n = 11). Participants ingested supplement doses daily, beginning 3 days prior to departure and continued until the highest sleeping altitude (4800 m) reached on day 17 of the expedition. Data were collected at baseline (44 m altitude), at 2350 m (day 9), 3400 m (day 12) and 4800 m (day 17).
Results
BRJ enhanced the salivary levels of nitrite (p = 0.007). There was a significant decrease in peripheral oxygen saturation and there were increases in heart rate, diastolic blood pressure, and rating of perceived exertion with increasing altitude (p=<0.001). Harvard Step Test fitness scores significantly declined at 4800 m in the control group (p = 0.003) compared with baseline. In contrast, there was no decline in fitness scores at 4800 m compared with baseline (p = 0.26) in the BRJ group. Heart rate recovery speed following exercise at 4800 m was significantly prolonged in the control group (p=<0.01) but was unchanged in the BRJ group (p = 0.61). BRJ did not affect the burden of HA illness (p = 1.00).
Conclusions
BRJ increases salivary nitrite levels and ameliorates the decline in fitness at altitude but does not affect the occurrence of HA illness.
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