The Acute Effect of Magnesium Supplementation on Endothelial Function: A Randomized Cross-Over Pilot Study
Murphy C, Byrne J, Keogh JB, Headland ML, Clifton PM
International journal of environmental research and public health · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-05-17 · Int J Environ Res Public Health · vol. 18 · número 10 · pág. 5303
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 6 citas · más que el 61% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention
- Palabras clave
- Medicine, Endothelial dysfunction, Randomized controlled trial, Magnesium, Pathogenesis, Body mass index, Internal medicine, Blood pressure, Gastroenterology
- MeSH
- brachial artery, endothelium, vascular, humans, magnesium, pilot projects, cross-over studies, dietary supplements, female, male
5 autores
- Caitríona Murphy🇦🇺🇮🇪University of South Australia; Technological University Dublin
- Jennifer Byrne🇦🇺🇮🇪University of South Australia; Technological University Dublin
- Jennifer B Keogh🇦🇺University of South Australia
- Michelle Louise Headland🇦🇺University of South Australia
- Peter Marshall Clifton🇦🇺 · autor de correspondenciaUniversity of South Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium (Mg) deficiency might be a catalyst in the process of endothelial dysfunction, an early event in the pathogenesis of atherosclerosis. The aim of this study was to determine the acute effect of an oral Mg supplement as compared to control on endothelial function assessed by flow-mediated dilatation (FMD). Nineteen participants (39 years, body mass index (BMI) 22.9 kg/m2) completed this randomized cross-over study. Blood pressure (BP) and FMD were measured and blood samples were taken before participants drank 200 mL water, with or without an over the counter Mg supplement (450 mg and 300 mg for men and women). Measurements were repeated at 60 and 120 min. There was a statistically significant two-way interaction between treatment and time on serum Mg (p = 0.037). A difference of -0.085 mm in FMD was observed 60-min post drink in the control group, as compared to baseline FMD, and no difference was observed in the supplement group as compared to baseline. Despite the non-significant interaction between treatment and time on FMD, once adjusted for baseline, the difference seen in the control group and the lack of change in the supplement group at 60 min post-drink suggests that Mg might attenuate the reduction in FMD post-prandially.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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