Financiado en parte por Baxter International, Baxter International Inc
Olive oil-based lipid emulsion is noninferior to soybean oil-based lipid emulsion in the acute care setting: A double-blind randomized controlled trial
Salazar E, Alenezi S, Schwenger KJP, Casselman S, Somlaw N, Kim P, Adjemian D, Lu Z, Lou W, Ma D, Allard JP
Nutrition (Burbank, Los Angeles County, Calif.) · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Baxter International
- Empresa
- Baxter International Inc
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-04-18 · Nutrition · vol. 89 · pág. 111283
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 66% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Clinical Nutrition and Gastroenterology · Central Venous Catheters and Hemodialysis · Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Palabras clave
- parenteral nutrition, prealbumin, C-reactive protein, acute care patients, non-inferiority, nutritional status, inflammation
- MeSH
- humans, soybean oil, fat emulsions, intravenous, fish oils, plant oils, parenteral nutrition, prospective studies, double-blind method, olive oil
11 autores
- Ennaliza Salazar🇸🇬🇨🇦National University of Singapore; University of Toronto; Singapore General Hospital; Toronto General Hospital; Duke-NUS Medical School
- Sultan Samah A Alenezi🇸🇦King Saud University
- Katherine J. P. Schwenger🇨🇦University of Toronto; Toronto General Hospital
- Sarah Casselman🇨🇦University of Toronto; Toronto General Hospital
- Nicha Somlaw🇹🇭Thai Red Cross Society; Chulalongkorn University; King Chulalongkorn Memorial Hospital
- Patricia Kim🇨🇦University of Toronto; Toronto General Hospital
- Daniela Adjemian🇨🇱Hospital Clínico de la Universidad de Chile; University of Chile
- Zihang Lu🇨🇦University of Toronto
- Wendy Y. W. Lou🇨🇦University of Toronto
- David W.L.🇨🇦University of Guelph
- Johane P. Allard🇨🇦 · autor de correspondenciaUniversity of Toronto; Toronto General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Olive oil (OO)-based intravenous lipid emulsion (IVLE) may have biological advantages for nutrition and inflammation status compared with soybean oil (SO)-based IVLE. We aimed to compare prealbumin levels during infusion of OO- or SO-based IVLE in patients receiving parenteral nutrition in the acute-care setting.
Methods
In this prospective, noninferiority, double blind randomized controlled efficacy trial, patients received either OO-based or SO-based IVLE after providing consent. Biochemical and nutrition parameters were collected at baseline and at 7 to 10 d after initiation of parenteral nutrition. Results are expressed as means (standard deviations).
Results
A total of 210 patients completed the study: 102 patients in the SO-based IVLE group and 108 patients in the OO-based IVLE group. Both groups had a significant increase in prealbumin levels from baseline (SO: 0.10 [0.06] versus 0.15 [0.08] g/L; P < 0.0001; OO: 0.11 [0.06] versus 0.16 [0.08] g/L; P < 0.0001), but mean changes between groups were not different (P = 0.53). OO-based IVLE was noninferior to SO-based IVLE in maintaining or increasing serum prealbumin levels, with 20% as the noninferiority margin at follow-up (least square geometric mean ratio [95% CI], 1.10 [0.83,1.47]; P = 0.50). There was a significant improvement in C-reactive protein levels from baseline within each group (SO: 83.24 [69.72] versus 53.4 [59.78] mg/dL; P < 0.0001; OO: 85.13 [68.14] versus 58.75 [60.11] mg/dL; P = 0.004), but mean changes between the groups were not different (P = 0.836). Mortality, length of stay, and infection rates were not different for both groups.
Conclusions
In this study, OO-based IVLE was not inferior to SO-based IVLE in maintaining or increasing the prealbumin level. The improvement of C-reactive protein levels and other clinical outcomes were not different for both groups.
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