Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial
MacIntosh BA, Ramsden CE, Honvoh G, Faurot KR, Palsson OS, Johnston AD, Lynch C, Anderson P, Igudesman D, Zamora D, Horowitz M, Gaylord S, Mann JD
Clinical nutrition (Edinburgh, Scotland) · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Alcohol Abuse and Alcoholism
- Gobierno
- National Institute on Aging
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- National Center for Complementary and Integrative Health
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCCIH NIH HHS
- Subvenciones
- National Center for Complementary and Integrative Health (R01 AT007813); National Institute on Alcohol Abuse and Alcoholism (1R01AT007813-01A1); National Institute on Aging (T-32 5T32AT3378-13); National Center for Complementary and Integrative Health (T-32 AT003378); National Institute on Alcohol Abuse and Alcoholism (T-32 5T32AT3378-13); National Institute on Aging (1R01AT007813-01A1); National Institutes of Health (1r01at007813-01a1); National Institutes of Health (UL1TR002489); National Center for Complementary and Integrative Health (1R01AT007813–01A1); National Center for Complementary and Integrative Health (T-32 5T32AT3378-13); National Institutes of Health (T-32 5T32AT3378-13); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK056350)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2021-05-11 · Clin Nutr · vol. 40 · número 6 · págs. 3859–3867
- Editorial
- Elsevier BV
- Citado
- 17 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Migraine and Headache Studies
- Palabras clave
- omega-3 fatty acids, EPA and DHA, linoleic acid, omega-6 fatty acids, dietary intervention, migraine, dietary adherence, diet acceptability, nutrition counseling, omega-3 supplementation, chronic pain, energy intake, body mass index, self-monitoring, 24-hour dietary recall, n-6/n-3 ratio, omega-3 index
- MeSH
- humans, fatty acids, omega-3, docosahexaenoic acids, fatty acids, omega-6, diet, double-blind method, research design, adult, female, male, chronic pain
13 autores
- Beth MacIntosh🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill; University of North Carolina Health Care
- Christopher E. Ramsden🇺🇸University of North Carolina at Chapel Hill; National Institutes of Health; National Institute on Alcohol Abuse and Alcoholism; National Institute on Aging
- Gilson Honvoh🇺🇸University of North Carolina at Chapel Hill
- Keturah R. Faurot🇺🇸University of North Carolina at Chapel Hill
- Olafur Steinn Palsson🇺🇸University of North Carolina at Chapel Hill
- Angela D. Johnston🇺🇸University of North Carolina at Chapel Hill
- Chanee Lynch🇺🇸University of North Carolina at Chapel Hill
- Paula Anderson🇺🇸University of North Carolina at Chapel Hill
- DARIA A. IGUDESMAN🇺🇸University of North Carolina at Chapel Hill
- Daisy Zamora🇺🇸University of North Carolina at Chapel Hill; National Institutes of Health; National Institute on Aging
- Mark S. Horowitz🇺🇸National Institutes of Health; National Institute on Aging
- Susan Ann Gaylord🇺🇸University of North Carolina at Chapel Hill
- John Douglas Mann🇺🇸University of North Carolina at Chapel Hill
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Increasing dietary intake of n-3 EPA+DHA and lowering dietary n-6 LA is under investigation as a therapeutic diet for improving chronic pain syndromes as well as other health outcomes. Herein we describe the diet methodology used to modulate intake of n-3 and n-6 PUFA in a free living migraine headache population and report on nutrient intake, BMI and diet acceptability achieved at week 16 of the intensive diet intervention and week 22 follow-up time-point.
Methods
A total of 178 participants were randomized and began one of three diet interventions: 1) a high n-3 PUFA, average n-6 PUFA (H3) diet targeting 1500 mg EPA+DHA/day and 7% of energy (en%) from n-6 linoleic acid (LA), 2) a high-n-3 PUFA, low-n-6 PUFA (H3L6) targeting 1500 mg EPA+DHA/day and <1.8 en% n-6 LA or 3) a Control diet with typical American intakes of both EPA+DHA (<150 mg/day) and 7 en% from n-6 LA. Methods used to achieve diet change to week 16 include diet education, diet counseling, supply of specially prepared foods, self-monitoring and access to online diet materials. Only study oils and website materials were provided for the follow-up week 16 to week 22 periods. Diet adherence was assessed by multiple 24 h recalls administered throughout the trial. Diet acceptability was assessed in a subset of participants at 4 time points by questionnaire.
Results
At week 16 H3 and H3L6 diet groups significantly increased median n-3 EPA+DHA intake from 48 mg/2000 kcals at baseline to 1484 mg/2000 kcals (p < 0.0001) and from 44 mg/2000 kcals to 1341 mg/2000 kcals (p < 0.0001), respectively. In the Control group, EPA+DHA intake remained below the typical American intake with baseline median at 60 mg/2000 kcals and 80 mg/2000 kcals (p = 0.6) at week 16. As desired, LA intake was maintained in the H3 and Control group with baseline median of 6.5 en% to 7.1 en% (p = 0.4) at week 16 and from 6.5 en% to 6.8 en% (p = 1.0) at week 16, respectively. In the H3L6 group, n-6 LA decreased from 6.3 en% at baseline to 3.2 en% (p < 0.0001) at week 16. There were no significant changes in BMI or diet acceptability throughout the trial or between diet groups.
Conclusions
We find this diet method to be acceptable to research participants and successful in altering dietary n-3 EPA+DHA with and without concurrent decreases in n-6 LA. If n-6 LA of less than 3 en% is desired, additional techniques to limit LA may need to be employed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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