The effect of n-3 polyunsaturated fatty acids-enriched hen eggs consumption on IgG and total plasma protein N-glycosylation in healthy individuals and cardiovascular patients
Stupin A, Cvetko A, Kralik G, Mihalj M, Šušnjara P, Kolobarić N, Breškić Ćurić Ž, Lukinac AM, Kibel A, Selthofer-Relatić K, Jukić I, Stupin M, Kolar L, Kralik Z, Grčević M, Galović O, Mihaljević Z, Matić A, Juranić B, Gornik O, Lauc G, Drenjančević I
Glycobiology · 4 citas
Etiquetas de revisión
Alimentación controladaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Josip Juraj Strossmayer Osijek
- Universidad u hospital
- Croatian National Scientific Center of Excellence for Personalized Health Care
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-06-07 · Glycobiology · vol. 31 · número 9 · págs. 1163–1175
- Editorial
- Oxford University Press
- Citado
- 3 citas · más que el 54% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Glycosylation and Glycoproteins Research · Diet, Metabolism, and Disease
- Palabras clave
- Polyunsaturated fatty acid, Fucosylation, Glycome, Glycan, Chemistry, Endocrinology, Internal medicine, Biochemistry, Fatty acid, Biology, Medicine, Glycoprotein
- MeSH
- animals, chickens, humans, fatty acids, omega-3, fatty acids, unsaturated, immunoglobulin g, glycosylation, female
22 autores
- Ana Stupin🇭🇷University of Osijek
- Ana Cvetko🇭🇷University of Zagreb
- Gordana Kralik🇭🇷University of Osijek
- Martina Mihalj🇭🇷University of Osijek
- Petar Šušnjara🇭🇷University of Osijek
- Nikolina Kolobarić🇭🇷University of Osijek
- Željka Breškić Ćurić🇭🇷Polytechnic of Međimurje in Čakovec
- Ana Marija Lukinac🇭🇷University of Osijek
- Aleksandar Kibel🇭🇷University of Osijek
- Kristina Selthofer-Relatić🇭🇷University of Osijek
- Ivana Jukić🇭🇷University of Osijek
- Marko Stupin🇭🇷University of Osijek
- Luka Kolar🇭🇷Polytechnic Lavoslav Ružička Vukovar
- Zlata Kralik🇭🇷University of Osijek
- Manuela Grčević🇭🇷University of Osijek
- Olivera Galović🇭🇷University of Osijek
- Zrinka Mihaljević🇭🇷University of Osijek
- Anita Matić🇭🇷University of Osijek
- Brankica Juranić🇭🇷University of Osijek
- Olga Gornik🇭🇷University of Zagreb
- Gordan Lauc🇭🇷🇺🇸University of Zagreb; Genos (Croatia); Science Research Laboratory
- Ines Drenjančević🇭🇷 · autor de correspondenciaUniversity of Osijek
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study determined the effect of n-3 polyunsaturated fatty acids (n-3 PUFAs)-enriched hen eggs consumption on immunoglobulin G (IgG) and total plasma protein N-glycan profiles and inflammatory biomarkers level in healthy individuals (N = 33) and cardiovascular (CV) patients (N = 21). Subjects were divided to Control-Healthy and Control-CV subgroups [consumed three regular hens' eggs/daily (249 mg n-3 PUFAs/day)], and n-3 PUFAs-Healthy and n-3 PUFAs-CV subgroups [consumed three n-3 PUFAs-enriched hen eggs/daily (1053 mg n-3 PUFAs/day)] for 3 weeks. Serum-free fatty acids profile and high-sensitivity C-reactive protein, interleukin 6 and 10 (IL-6, IL-10) and tumor necrosis factor alpha were measured. Total plasma protein and IgG N-glycome have been profiled before and after dietary protocols. Serum n-3 PUFAs concentration significantly increased following n-3 PUFAs hen eggs consumption in both n-3 PUFAs-Healthy and n-3 PUFAs-CV. IL-10 significantly increased in both Healthy subgroups, whereas no change occurred in CV subgroups. Derived IgG N-glycan traits: bisecting N-acetylglucosamine (B) significantly decreased in n-3 PUFAs-Healthy, whereas agalactosylation (G0) and core fucosylation (CF) significantly increased in Control-Healthy. Derived total plasma protein N-glycan traits: high branching glycans, trigalactosylation, tetragalactosylation, trisialylation, tetrasialylation and antennary fucosylation significantly decreased, whereas G0, monogalactosylation (G1), neutral glycans (S0), B, CF and oligomannose structures significantly increased in n-3 PUFAs-CV. Digalactosylation significantly decreased, and G0, G1, S0, disialylation, B and CF significantly increased in Control-CV. n-3 PUFAs consumption alters IgG N-glycan traits and IL-10 in healthy individuals, and total plasma protein N-glycan traits in CV patients, by shifting them toward less inflammatory N-glycosylation profile.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.