A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults
Templeman I, Smith HA, Chowdhury E, Chen YC, Carroll H, Johnson-Bonson D, Hengist A, Smith R, Creighton J, Clayton D, Varley I, Karagounis LG, Wilhelmsen A, Tsintzas K, Reeves S, Walhin JP, Gonzalez JT, Thompson D, Betts JA
Science translational medicine · 95 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Nottingham Trent University
- Universidad u hospital
- Trent University
- Universidad u hospital
- University of Bath
Según 3 financiadores declarados.
Publicación
- Publicado
- 2021-06-16 · Sci Transl Med · vol. 13 · número 598
- Editorial
- American Association for the Advancement of Science
- Citado
- 114 citas · más que el 99% de estudios similares · 9.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Regulation of Appetite and Obesity
- Palabras clave
- Intermittent fasting, Weight loss, Randomized controlled trial, Medicine, Calorie restriction, Body weight, Energy metabolism, Physiology, Environmental health, Internal medicine, Obesity
- MeSH
- humans, obesity, body weight, weight loss, caloric restriction, fasting, body composition, energy metabolism, energy intake, adult
19 autores
- Iain Templeman🇬🇧University of Bath
- Harry Smith🇬🇧University of Bath
- Enhad A. Chowdhury🇬🇧University of Bath
- Yung-Chih Chen🇹🇼🇬🇧National Taiwan Normal University; University of Bath
- Harriet A. Carroll🇸🇪🇬🇧Lund University; University of Bath
- Drusus Johnson-Bonson🇬🇧University of Bath
- Aaron Hengist🇬🇧University of Bath
- Rowan Smith🇬🇧University of Bath
- Jade V. Creighton🇬🇧University of Bath; Nottingham Trent University
- David J. Clayton🇬🇧Nottingham Trent University
- Ian Varley🇬🇧Nottingham Trent University
- Leonidas G. Karagounis🇨🇭University of Bern; Nestlé (Switzerland); Institute of Social and Preventive Medicine
- Andrew Wilhelmsen🇬🇧Arthritis UK
- Kostas Tsintzas🇬🇧Arthritis UK
- Sue Reeves🇬🇧University of Roehampton
- Jean‐Philippe Walhin🇬🇧University of Bath
- Javier Thomas Gonzalez🇬🇧University of Bath
- Dylan Thompson🇬🇧University of Bath
- James A. Betts🇬🇧 · autor de correspondenciaUniversity of Bath
Resumen
El texto original del estudio, en el idioma en que se publicó.
Intermittent fasting may impart metabolic benefits independent of energy balance by initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour fasting with 150% energy intake on alternate days for 3 weeks in lean, healthy individuals (0:150; n = 12). Control groups involved a matched degree of energy restriction applied continuously without fasting (75% energy intake daily; 75:75; n = 12) or a matched pattern of fasting without net energy restriction (200% energy intake on alternate days; 0:200; n = 12). Primary outcomes were body composition, components of energy balance, and postprandial metabolism. Daily energy restriction (75:75) reduced body mass (-1.91 ± 0.99 kilograms) almost entirely due to fat loss (-1.75 ± 0.79 kilograms). Restricting energy intake via fasting (0:150) also decreased body mass (-1.60 ± 1.06 kilograms; P = 0.46 versus 75:75) but with attenuated reductions in body fat (-0.74 ± 1.32 kilograms; P = 0.01 versus 75:75), whereas fasting without energy restriction (0:200) did not significantly reduce either body mass (-0.52 ± 1.09 kilograms; P ≤ 0.04 versus 75:75 and 0:150) or fat mass (-0.12 ± 0.68 kilograms; P ≤ 0.05 versus 75:75 and 0:150). Postprandial indices of cardiometabolic health and gut hormones, along with the expression of key genes in subcutaneous adipose tissue, were not statistically different between groups (P > 0.05). Alternate-day fasting less effectively reduces body fat mass than a matched degree of daily energy restriction and without evidence of fasting-specific effects on metabolic regulation or cardiovascular health.
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