The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose-response Meta-analysis of Randomized Clinical Trials
Talebi S, Miraghajani M, Hosseini R, Mohammadi H
Biological trace element research · 11 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-06-18 · Biol Trace Elem Res · vol. 200 · número 4 · págs. 1538–1550
- Editorial
- Springer Science+Business Media
- Citado
- 15 citas · más que el 51% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 51 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Magnesium Alloys: Properties and Applications · Magnesium Oxide Properties and Applications
- Palabras clave
- magnesium supplementation, oral magnesium, inflammatory markers, C-reactive protein, interleukin-6, TNF-α, dose-response relationship, adults
- MeSH
- humans, inflammation, magnesium, c-reactive protein, dietary supplements, adult, randomized controlled trials as topic, biomarkers
4 autores
- Sepide Talebi🇮🇷Tehran University of Medical Sciences
- Maryam Sadat Miraghajani🇬🇧🇮🇷University of Nottingham; Shahid Beheshti University; Shahid Beheshti University of Medical Sciences
- Reza Hosseini🇮🇷Isfahan University of Medical Sciences
- Hamed Mohammadi🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
This is a comprehensive systematic review and dose-response meta-analysis evaluating the effects of oral magnesium supplementation on inflammatory biomarkers including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) among adults. The major databases including PubMed, Web of Science, Embase, and Google Scholar were searched for relevant publications until December 14, 2020, using appropriate keywords. The Cochrane Collaboration tool was used to assess the quality of each study. We also performed a subgroup analysis to identify probable sources of heterogeneity. A total of 18 studies with 927 participants fulfilled the eligibility criteria and included in this meta-analysis. Our results indicate that the supplementation with magnesium had no statistically significant effect on serum concentrations of CRP (WMD, - 0.49; 95% CI, - 1.72 to 0.75 mg/L; P = 0.44), IL-6 (WMD, - 0.03; 95% CI, - 0.40 to 0.33 pg/mL; P = 0.86), and TNF-α (WMD, 0.12; 95% CI, - 0.08 to 0.31 pg/mL; P = 0.24) compared with controls. In addition, based on dose-response assessment, no significant non-linear association was found between magnesium supplementation dosage or duration on serum CRP and IL-6 concentrations. The findings of the present systematic review and meta-analysis did not support the notion that oral magnesium supplementation could have favorable effects on CRP, IL-6, and TNF-α in the adult population.
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