Analysis of Clinical Trial Registry of India for Evidence of Anti-Arthritic Properties of Withania somnifera (Ashwagandha)
Kanjilal S, Gupta AK, Patnaik RS, Dey A
Alternative therapies in health and medicine · 5 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-11-01 · Altern Ther Health Med · vol. 27 · número 6 · págs. 58–66
- Editorial
- National Institutes of Health
- Citado
- 12 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 0 trabajos
- Acceso
- De pago
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Pharmacology and Nanomedicine Research · Andrographolide Research and Applications
- Palabras clave
- Withania somnifera, Medicine, Clinical trial, Placebo, Arthritis, Traditional medicine, Alternative medicine, Randomized controlled trial, Physical therapy, Surgery, Internal medicine, Pathology
- MeSH
- humans, withania, plant extracts, registries, retrospective studies, india
4 autores
- Satyajyoti Kanjilal
- Ashok Kumar Gupta
- Ranjana Saksena Patnaik
- Amitabha Dey
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Withania somnifera (Ashwagandha) is an herb with anti-inflammatory properties used in managing arthritis. There is significant clinical data in the public domain on the effects of Ashwagandha and this study was aimed at compiling and analysing these data in a structured manner. The major sources of evidence data were clinical trials and systematic review of extant literature.
Methodology
Retrospective database search was conducted in the Clinical Trial Registry of India for trials registered from April 2008 to March 2020, and published literature related to the anti-arthritic effects of Withania somnifera were reviewed.
Results
In all, 77 registered clinical trials were analysed and common among them were interventional, single-centre, randomized, double-blind, two-arm studies with Placebo being the comparator. Similar findings were observed in the 10 published clinical trials on arthritis evaluated for this study. While industry- and government-sponsored trials were identified, government funded sites with approvals from Institutional Ethics Committees were preferred. Most trials were registered as Phase 2 with the highest number of sites in the state of Maharashtra. The solid dosage form was most preferred.
Conclusion
While the effects of Withania somnifera on various disorders are being investigated by several clinical trials, the ones evaluated for this study provide insight on its potential in managing arthritis when given for a specific duration. Evidence shows a dosage of 6 gm in powder form or extracts in tablets, or 500 -1000 mg capsule consumed for a duration of 8 - 12 weeks may be useful in managing symptoms of arthritis in patients.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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