Body mass-normalized moderate dose of dietary nitrate intake improves endothelial function and walking capacity in patients with peripheral artery disease
Pekas EJ, Wooden TK, Yadav SK, Park SY
American journal of physiology. Regulatory, integrative and comparative physiology · 24 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Nebraska Space Grant Consortium
- Gobierno
- National Institute of General Medical Sciences
- Universidad u hospital
- University of Nebraska at Omaha
- Gobierno
- NASA Nebraska Space Grant
- Gobierno
- NIGMS NIH HHS
- Gobierno
- Center for Research in Human Movement Variability National Institutes of Health
- Gobierno
- HHS | NIH | National Institute of General Medical Sciences
- Gobierno
- NASA Nebraska Space Grant Fellowship
- Subvenciones
- National Institute of General Medical Sciences (P20GM109090); Nebraska Space Grant Consortium (NNX15AI09H)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2021-06-23 · Am J Physiol Regul Integr Comp Physiol · vol. 321 · número 2 · págs. R162–R173
- Editorial
- American Physiological Society
- Citado
- 33 citas · más que el 95% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 82 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Peripheral Artery Disease Management · Cerebrovascular and Carotid Artery Diseases · Cardiovascular Health and Disease Prevention
- Palabras clave
- Claudication, Pulse wave velocity, Brachial artery, Medicine, Blood pressure, Crossover study, Nitrate, Internal medicine, Arterial stiffness, Nitrite, Cardiology, Placebo, Hemoglobin, Vasodilation, Anesthesia, Vascular disease, Chemistry, Arterial disease, Pathology
- MeSH
- endothelium, vascular, humans, beta vulgaris, intermittent claudication, nitrates, body mass index, treatment outcome, walking, cross-over studies, double-blind method, recovery of function, blood pressure, vasodilation, exercise tolerance, time factors, aged, middle aged, nebraska, female, male, peripheral arterial disease, vascular stiffness, fruit and vegetable juices
4 autores
- Elizabeth J. Pekas🇺🇸University of Nebraska at Omaha
- TeSean K. Wooden🇺🇸University of Nebraska at Omaha
- Santosh Kumar Yadav🇺🇸University of Nebraska Medical Center
- Song‐Young Park🇺🇸 · autor de correspondenciaUniversity of Nebraska at Omaha
Resumen
El texto original del estudio, en el idioma en que se publicó.
Peripheral artery disease (PAD) is characterized by the accumulation of atherosclerotic plaques in the lower extremity conduit arteries, which impairs blood flow and walking capacity. Dietary nitrate has been used to reduce blood pressure (BP) and improve walking capacity in PAD. However, a standardized dose for PAD has not been determined. Therefore, we sought to determine the effects of a body mass-normalized moderate dose of nitrate (0.11 mmol nitrate/kg) as beetroot juice on serum nitrate/nitrite, vascular function, walking capacity, and tissue oxygen utilization capacity in patients with PAD. A total of 11 patients with PAD received either nitrate supplement or placebo in a randomized crossover design. Total serum nitrate/nitrite, resting BP, brachial and popliteal artery endothelial function (flow-mediated dilation, FMD), arterial stiffness (pulse-wave velocity, PWV), augmentation index (AIx), maximal walking distance and time, claudication onset time, and skeletal muscle oxygen utilization were measured pre- and postnitrate and placebo intake. There were significant group × time interactions (P P > 0.05). These results indicate that a body-mass normalized moderate dose of nitrate may be effective and safe for reducing BP, improving endothelial function, and improving walking capacity in patients with PAD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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