Does four-week consecutive, dawn-to-sunset intermittent fasting during Ramadan affect cardiometabolic risk factors in healthy adults? A systematic review, meta-analysis, and meta-regression
Jahrami HA, Faris ME, I Janahi A, I Janahi M, Abdelrahim DN, Madkour MI, Sater MS, Hassan AB, Bahammam AS
Nutrition, metabolism, and cardiovascular diseases : NMCD · 80 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-05-24 · Nutr Metab Cardiovasc Dis · vol. 31 · número 8 · págs. 2273–2301
- Editorial
- Elsevier BV
- Citado
- 98 citas · más que el 93% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 229 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Birth, Development, and Health
- Palabras clave
- Ramadan fasting, intermittent fasting, cardiometabolic risk factors, lipid profile, blood pressure, heart rate, triglycerides, LDL cholesterol, HDL cholesterol, VLDL cholesterol, total cholesterol, healthy adults, meal timing
- MeSH
- humans, cardiovascular diseases, lipids, fasting, risk assessment, age factors, sex factors, blood pressure, time factors, holidays, islam, religion and medicine, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, young adult, protective factors, biomarkers, cardiometabolic risk factors
9 autores
- Haitham Jahrami🇧🇭Ministry of Health; Arabian Gulf University
- MoezAlIslam E. Faris🇦🇪 · autor de correspondenciaUniversity of Sharjah
- Abdulrahman Ismaeel Janahi🇧🇭Arabian Gulf University
- Mohamed I. Janahi🇧🇭Arabian Gulf University
- Dana N. Abdelrahim🇯🇴University of Jordan
- Mohamed Ibrahim Madkour🇦🇪University of Sharjah
- Mai S. Sater🇧🇭Arabian Gulf University
- Adla Bakri Hassan🇧🇭Arabian Gulf University
- Ahmed S. Bahammam🇸🇦King Saud University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
This study aimed to evaluate the effects of Ramadan diurnal intermittent fasting (RDIF; 29-30 days) on cardiometabolic risk factors (CMRF) in healthy adults, and examine the effect of various cofactors on the outcomes using sub-group meta-regression.
Data synthesis
We conducted a systematic review and meta-analysis to measure the effect sizes of changes in CMRF in healthy adult Muslims observing RDIF. Ten scientific databases (EBSCOhost, CINAHL, Cochrane, EMBASE, PubMed/MEDLINE, Scopus, Google Scholar, ProQuest Medical, ScienceDirect, and Web of Science) were searched from the date of inception (1950) to the end of November 2020. The CMRF searched and analyzed were total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), diastolic blood pressure (DBP), and heart rate (HR). We identified 91 studies (4431 adults aged 18-85 years) conducted between 1982 and 2020 in 23 countries distributed over four continents. RDIF-induced effect sizes for CMRF were: TC (no. of studies K = 77, number of subjects N = 3705, Hedge's g = -0.092, 95% confidence interval (CI): -0.168, 0.016); TG (K = 74, N = 3591, Hedge's g = -0.127, 95% CI: -0.203, 0.051); HDL-C (K = 68, N = 3528, Hedge's g = 0.138, 95% CI: 0.051, 0.224); LDL-C (K = 65, N = 3354, Hedge's g = -0.115, 95% CI: -0.197, -0.034); VLDL-C (K = 13, N = 648, Hedge's g = -0.252, 95% CI: -0.431, 0.073), DBP (K = 32, N = 1716, Hedge's g = -0.255, 95% CI: -0.363, 0.147), and HR (K = 12, N = 674, Hedge's g = -0.082, 95% CI: -0.300, 0.136). Meta-regression revealed that the age of fasting people was a significant moderator of changes in both HDL-C (P = 0.02) and VLDL-C (P = 0.01). Male sex was the only significant moderator of changes in LDL-C (P = 0.055). Fasting time duration was the only significant moderator of HDL-C (P = 0.001) at the end of Ramadan.
Conclusions
RDIF positively impacts CMRF, which may confer short-term transient protection against cardiovascular disease among healthy people.
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