Ultra-processed food is associated with features of metabolic syndrome and non-alcoholic fatty liver disease
Ivancovsky-Wajcman D, Fliss-Isakov N, Webb M, Bentov I, Shibolet O, Kariv R, Zelber-Sagi S
Liver international : official journal of the International Association for the Study of the Liver · 62 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciación no declaradaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio transversal (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-06-26 · Liver Int · vol. 41 · número 11 · págs. 2635–2645
- Editorial
- Wiley
- Citado
- 84 citas · más que el 99% de estudios similares · 11.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Food composition and properties
- Palabras clave
- Fatty liver, Metabolic syndrome, Alcoholic liver disease, Disease, Medicine, Gastroenterology, Internal medicine, Obesity, Cirrhosis
- MeSH
- humans, hypertension, ultrasonography, cross-sectional studies, aged, middle aged, female, male, non-alcoholic fatty liver disease, metabolic syndrome
7 autores
- Dana Ivancovsky Wajcman🇮🇱University of Haifa
- Naomi Fliss Isakov
- Muriel Webb🇮🇱Tel Aviv University
- Itay Bentov🇺🇸University of Washington
- Oren Shibolet🇮🇱Tel Aviv University
- Revital Kariv🇮🇱Tel Aviv University
- Shira Zelber‐Sagi🇮🇱 · autor de correspondenciaUniversity of Haifa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
High consumption of ultra-processed food (UPF) is associated with mortality and chronic morbidity but has not been studied concerning to non-alcoholic fatty liver disease (NAFLD). We aimed to test the association of UPF consumption with metabolic syndrome, NAFLD and related-liver damage.
Methods
A cross-sectional study among volunteers who underwent abdominal ultrasound (AUS), anthropometrics, blood pressure measurements, and fasting blood tests including FibroMax for non-invasive assessment of NASH and significant fibrosis. A food-frequency questionnaire was used to evaluate UPF consumption using the NOVA classification.
Results
A total of 789 subjects were included in the total sample (mean age 58.83 ± 6.58 years, 52.60% men), a reliable FibroMax test was obtained from 714 subjects, 305 subjects were diagnosed with NAFLD. High consumption of UPF was associated with higher odds for metabolic syndrome (OR = 1.88, 95% CI 1.31-2.71, P = .001) and its components; hypertension, hypertriglyceridemia, and low HDL, among the entire sample (OR = 1.53, 1.07-2.19, P = .026; OR = 1.51, 1.08-2.11, P = .017; OR = 1.55, 1.05-2.29, P = .028). In addition, it was associated with higher odds for NASH and hypertension (OR = 1.89, 1.07-3.38, P = .030; OR = 2.26, 1.20-4.26, P = .012 respectively) among subjects with NAFLD. Stratification by smoking status revealed an association between high UPF consumption and significant fibrosis among ever smokers in the entire sample and among subjects with NAFLD (OR = 1.89, 95% CI 1.03-3.45, P = .039; OR = 2.85, 1.14-7.14, P = .026 respectively).
Conclusions
High UPF consumption is associated with metabolic syndrome in the general population, and among those with NAFLD it is associated with NASH marker. Ever-smoking may act synergistically with UPF to amplify the risk for fibrosis.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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