Associations of Changes in Blood Lipid Concentrations with Changes in Dietary Cholesterol Intake in the Context of a Healthy Low-Carbohydrate Weight Loss Diet: A Secondary Analysis of the DIETFITS Trial
Vergara M, Hauser ME, Aronica L, Rigdon J, Fielding-Singh P, Shih CW, Gardner CD
Nutrients · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
- Gobierno
- National Institutes of Health
- Gobierno
- Horizon 2020 Framework Programme
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (1R01DK091831); National Center for Advancing Translational Sciences (UL1TR003142); Horizon 2020 Framework Programme (No 701944); National Institutes of Health (T32HL007034); National Institutes of Health (UL1-TR001085)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-06-04 · Nutrients · vol. 13 · número 6 · pág. 1935
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 4 citas · más que el 55% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Diet and metabolism studies · Nutritional Studies and Diet · Pharmacology and Obesity Treatment
- Palabras clave
- Cholesterol, Context (archaeology), Medicine, Carbohydrate, Body mass index, Internal medicine, Endocrinology, Biology
- MeSH
- humans, obesity, lipids, cholesterol, dietary, triglycerides, diet, reducing, adolescent, adult, middle aged, female, male, diet, carbohydrate-restricted, cholesterol, ldl, young adult, diet, healthy
7 autores
- Mónica Vergara🇺🇸Stanford University
- Michelle E. Hauser🇺🇸VA Palo Alto Health Care System; San Mateo County Health System; Stanford University
- Lucia Aronica🇺🇸Stanford University
- Joseph Rigdon🇺🇸Stanford University
- Priya Fielding‐Singh🇺🇸University of Utah; Huntsman Cancer Institute
- Cynthia W. Shih🇺🇸Stanford University
- Christopher D. Gardner🇺🇸 · autor de correspondenciaStanford University
Resumen
El texto original del estudio, en el idioma en que se publicó.
In 2015, the Dietary Guidelines for Americans (DGA) eliminated the historical upper limit of 300 mg of dietary cholesterol/day and shifted to a more general recommendation that cholesterol intake should be limited. The primary aim of this secondary analysis of the Diet Intervention Examining the Factors Interacting With Treatment Success (DIETFITS) weight loss diet trial was to evaluate the associations between 12-month changes in dietary cholesterol intake (mg/day) and changes in plasma lipids, particularly low-density lipoprotein (LDL) cholesterol for those following a healthy low-carbohydrate (HLC) diet. Secondary aims included examining high-density lipoprotein (HDL) cholesterol and triglycerides and changes in refined grains and added sugars. The DIETFITS trial randomized 609 healthy adults aged 18-50 years with body mass indices of 28-40 kg/m2 to an HLC or healthy low-fat (HLF) diet for 12 months. Linear regressions examined the association between 12-month change in dietary cholesterol intake and plasma lipids in 208 HLC participants with complete diet and lipid data, adjusting for potential confounding variables. Baseline dietary cholesterol intake was 322 ± 173 (mean ± SD). At 12 months, participants consumed an average of 460 ± 227 mg/day of dietary cholesterol; 76% consumed over the previously recommended limit of 300 mg/day. Twelve-month changes in cholesterol intake were not significantly associated with 12-month changes in LDL-C, HDL-C, or triglycerides. Diet recall data suggested participants' increase in dietary cholesterol was partly due to replacing refined grains and sugars with eggs. An increase in daily dietary cholesterol intake to levels substantially above the previous 300 mg upper limit was not associated with a negative impact on lipid profiles in the setting of a healthy, low-carbohydrate weight loss diet.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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