Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms
Abiri B, Sarbakhsh P, Vafa M
Nutritional neuroscience · 32 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Medical Research Development
- Subvenciones
- National Institute for Medical Research Development (982923)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-07-02 · Nutr Neurosci · vol. 25 · número 10 · págs. 2123–2135
- Editorial
- Taylor & Francis
- Citado
- 49 citas · más que el 91% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Vitamin D Research Studies · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Mood, Inflammation, Randomized controlled trial, Depressive symptoms, Medicine, Internal medicine, Vitamin D and neurology, Vitamin, Endocrinology, Psychology, Physical therapy, Anxiety, Clinical psychology, Psychiatry
- MeSH
- humans, obesity, inflammation, magnesium, brain-derived neurotrophic factor, vitamins, vitamin d, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, double-blind method, depression, dietary supplements, female, sirtuin 1
3 autores
- Behnaz Abiri🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Parvin Sarbakhsh🇮🇷Tabriz University of Medical Sciences
- Mohammadreza Vafa🇮🇷 · autor de correspondenciaIran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
This study aimed to evaluate the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms.
Methods
In this trial, the 108 obese women with mild to moderate depressive symptoms were randomly allocated into 4 groups: (1) co- supplementation group (n = 27): receiving a 50000 IU vitamin D soft gel weekly + a 250- mg magnesium tablet daily; (2) vitamin D group (n = 27): receiving a 50000 IU vitamin D soft gel weekly + a magnesium placebo daily; (3) magnesium group (n = 27): receiving a vitamin D placebo weekly + a 250- mg magnesium tablet daily; (4) control group (n = 27): receiving a vitamin D placebo weekly + a magnesium placebo daily, for 8 weeks. Before and after the intervention, anthropometric indices, depressive symptoms, serum levels of BDNF, 25(OH)-D, inflammation, and SIRT1, were measured.
Results
At the end of the study, ANCOVA demonstrated significant differences between the 4 groups in 25(OH)-D, magnesium, TNF-α, IL-6, and BDNF levels. But, we found no significant differences in terms of hs-CRP and SIRT1 levels. A significant reduction in depression score was observed in 3 intervention groups and also in control group. No significant differences in BDI-II score were shown among the 4 groups at the end of the intervention.
Conclusion
Vitamin D plus magnesium supplementation in obese women with mild to moderate depressive symptoms has beneficial influences on mood, serum levels of BDNF, inflammation, and SIRT1.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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