Intake of processed meat, but not sodium, is associated with risk of colorectal cancer: Evidence from a large prospective cohort and two-sample Mendelian randomization
Feng Q, Wong SH, Zheng J, Yang Q, Sung JJ, Tsoi KK
Clinical nutrition (Edinburgh, Scotland) · 11 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Medical Research Council
- Subvenciones
- Medical Research Council (MC_PC_17228)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-06-14 · Clin Nutr · vol. 40 · número 7 · págs. 4551–4559
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 88% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Nutritional Studies and Diet · Sodium Intake and Health · Colorectal Cancer Screening and Detection
- Palabras clave
- processed meat, colorectal cancer, sodium intake, 24-hour urinary sodium excretion, cancer risk, Western diet, cancer prevention, dietary factors
- MeSH
- humans, colorectal neoplasms, sodium, sodium, dietary, diet, incidence, proportional hazards models, prospective studies, food handling, meat, middle aged, biological specimen banks, female, male, genome-wide association study, mendelian randomization analysis, united kingdom
6 autores
- Qi Feng🇭🇰Chinese University of Hong Kong
- Sunny Hei Wong🇭🇰Chinese University of Hong Kong
- Jie Zheng🇬🇧University of Bristol; MRC Integrative Epidemiology Unit
- Qian Yang🇬🇧University of Bristol; MRC Integrative Epidemiology Unit
- Joseph J.�Y. Sung🇭🇰Chinese University of Hong Kong
- Kelvin K.F. Tsoi🇭🇰 · autor de correspondenciaChinese University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Processed meat and high sodium intake are common in Western diet. The objective was to examine their independent effects on the risk of colorectal cancer (CRC).
Methods
We performed both observational analysis with UK Biobank and genetic analysis with Mendelian randomization (MR). The 24-h urinary sodium (UNa) and reported intake of processed meat were fitted on incident CRC by multivariable Cox proportional hazard model, adjusted for covariates, such as age, gender, family history, etc. Different sodium measures were used for sensitivity analyses. Two-sample MR analyses were performed using summary data from genome-wide association studies of UNa and CRC. Multivariable MR was adjusted for body mass index.
Results
We included 415 524 eligible participants from UK Biobank. During a median follow-up of 11.1 years, 2663 participants were diagnosed with CRC. High intake of processed meat independently increased risk of CRC by 23% (HR 1.23; 95% CI: 1.03 to 1.46), but 24-h UNa was not significantly associated with CRC (HR 0.96; 95% CI: 0.87 to 1.06). Furthermore, MR also showed little evidence for the effect of UNa on CRC (OR 1.02; 95% CI: 0.11 to 9.42). Sensitivity analyses showed consistent results across different measurements of sodium intake.
Conclusions
Intake of processed meat had an independent effect on the risk of CRC, but the risk was not associated with sodium level. Reduction of processed meat intake may be an effective strategy for CRC prevention, while sodium reduction should still be recommended to achieve other health benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.