Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients
Zanforlini BM, Ceolin C, Trevisan C, Alessi A, Seccia DM, Noale M, Maggi S, Guarnieri G, Vianello A, Sergi G
Aging clinical and experimental research · 26 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Università degli Studi di Padova
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-07-14 · Aging Clin Exp Res · vol. 34 · número 1 · págs. 167–174
- Editorial
- Springer Science+Business Media
- Citado
- 34 citas · más que el 88% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 35 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Chronic Obstructive Pulmonary Disease (COPD) Research · Cystic Fibrosis Research Advances
- Palabras clave
- Medicine, COPD, Placebo, Spirometry, Quality of life (healthcare), Physical therapy, Randomized controlled trial, Internal medicine, Volunteer, Clinical trial
- MeSH
- humans, pulmonary disease, chronic obstructive, disease progression, magnesium, hand strength, quality of life, dietary supplements, aged
10 autores
- Bruno Micael Zanforlini🇮🇹University of Padua
- Chiara Ceolin🇮🇹 · autor de correspondenciaUniversity of Padua
- Caterina Trevisan🇮🇹University of Padua
- Agnese Alessi🇮🇹University of Padua
- Daniele Michele Seccia🇮🇹University of Padua
- Marianna Noale🇮🇹Neuroscience Institute; National Research Council
- Stefania Maggi🇮🇹Neuroscience Institute; National Research Council
- Gabriella Guarnieri🇮🇹University of Padua
- Andrea Vianello🇮🇹University of Padua
- Giuseppe Sergi🇮🇹University of Padua
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
COPD is a common chronic condition in older age that impacts on daily activities and quality of life. Previous studies suggest that magnesium deficit in COPD patients affects bronco-obstruction, inflammation, and physical performance. We investigated whether oral magnesium supplementation in stable-phase COPD patients improves lung function, physical performance, and quality of life.
Methods
We conducted a double-blind randomized-controlled clinical study with 49 participants divided into two groups: one given 300 mg/day of magnesium citrate (n = 25) and the other one sachet/day of a placebo (n = 24). The following parameters were assessed at baseline and after 3 and 6 months: lung function (spirometry), physical performance (handgrip strength, lower limb strength, six-minute walk test), inflammation (e.g., C-reactive protein, CRP), disease-related symptoms, and quality of life (St George's Respiratory Questionnaire, EuroQoL-5D, the Modified British Medical Research Council Questionnaire).
Results
Linear mixed models revealed significantly lower CRP values in the intervention group than in the placebo group at the 6 month follow-up (β = - 3.2, 95% CI - 6.0, - 0.4, p = 0.03). Moreover, the maximum work for flexion tended to increase in both groups between the 3 and the 6 month assessments, especially in the placebo group. No significant differences within and between groups over the study period were observed for the other parameters tested.
Conclusions
Although the established minimum sample size was not reached, our results suggests that oral magnesium supplementation may have a potential anti-inflammatory role. On the other hand, it does not seem to substantially influence lung function, physical performance, and quality of life in COPD patients.
Trial registration
The study is registered in clinicaltrial.gov (Trial Registration: NCT02680769, 13 June 2016, retrospectively registered).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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