Financiado en parte por AstraZeneca, GlaxoSmithKline, Sanofi, AFA Försäkring, Servier
Association of ultra-processed food intake with risk of inflammatory bowel disease: prospective cohort study
Narula N, Wong ECL, Dehghan M, Mente A, Rangarajan S, Lanas F, Lopez-Jaramillo P, Rohatgi P, Lakshmi PVM, Varma RP, Orlandini A, Avezum A, Wielgosz A, Poirier P, Almadi MA, Altuntas Y, Ng KK, Chifamba J, Yeates K, Puoane T, Khatib R, Yusuf R, Boström KB, Zatonska K, Iqbal R, Weida L, Yibing Z, Sidong L, Dans A, Yusufali A, Mohammadifard N, Marshall JK, Moayyedi P, Reinisch W, Yusuf S
BMJ (Clinical research ed.) · 273 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciado por la industriaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- AstraZeneca
- Empresa
- GlaxoSmithKline
- Empresa
- Sanofi
- Organización sin fines de lucro
- Heart and Stroke Foundation of Canada
- Gobierno
- Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
- Universidad u hospital
- Hamilton Health Sciences
- Gobierno
- Public Health Agency of Canada
- Gobierno
- International Development Research Centre
- Gobierno
- National Research Foundation
- Gobierno
- South Africa Netherlands research Programme on Alternatives in Development
- Gobierno
- Indian Council of Medical Research
- Gobierno
- Public Health Agency
- Gobierno
- Forskningsrådet för Arbetsliv och Socialvetenskap
- Gobierno
- Svenska Forskningsrådet Formas
- Universidad u hospital
- King Saud University
- Empresa
- AFA Försäkring
- Gobierno
- Ministério da Ciência, Tecnologia e Inovação
- Gobierno
- Vetenskapsrådet
- Universidad u hospital
- Universiti Kebangsaan Malaysia
- Universidad u hospital
- Universiti Teknologi MARA
- Universidad u hospital
- North-West University
- Universidad u hospital
- Universidad de La Frontera
- Universidad u hospital
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
- Empresa
- Servier
- Universidad u hospital
- Independent University, Bangladesh
- Universidad u hospital
- Serbian Academy of Sciences and Arts
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Medical Research Council
- Gobierno
- Philippine Council for Health Research and Development
- Universidad u hospital
- Faculty of Community and Health Sciences, University of the Western Cape
- Subvenciones
- Canadian Institutes of Health Research (6566-04-18062); Canadian Institutes of Health Research (290/W-PURE/2008/0); Universiti Teknologi MARA (UKM-Hejim-Komuniti-15-2010); Universiti Kebangsaan Malaysia (15-2010); Universiti Kebangsaan Malaysia (UKM-Hejim-Komuniti-15-2010); Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) (6566-04-18062)
Según 30 financiadores declarados.
Publicación
- Publicado
- 2021-07-14 · BMJ · vol. 374 · pág. n1554
- Citado
- 370 citas · más que el 100% de estudios similares · 44.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Nutrition and Health in Aging
- Palabras clave
- Inflammatory bowel disease, Prospective cohort study, Medicine, Inflammatory Bowel Diseases, Cohort study, Cohort, Internal medicine, Disease, Environmental health
- MeSH
- humans, colitis, ulcerative, crohn disease, proportional hazards models, prospective studies, causality, energy intake, adult, aged, middle aged, female, male, diet, western
35 autores
- Neeraj Narula🇨🇦🇫🇷 · autor de correspondenciaPopulation Health Research Institute; Institut de Recherche en Santé Digestive; Hamilton Health Sciences; McMaster University
- Emily C L Wong🇨🇦Population Health Research Institute; McMaster University
- Mahshid Dehghan🇨🇦Population Health Research Institute; Hamilton Health Sciences; McMaster University
- Andrew Mente🇨🇦Population Health Research Institute; Hamilton Health Sciences; McMaster University
- Sumathy Rangarajan🇨🇦Population Health Research Institute; Hamilton Health Sciences; McMaster University
- Fernando Tomas Lanas🇨🇱Universidad de La Frontera
- Patricio López‐Jaramillo🇨🇴Universidad De Santander
- Priyanka Rohatgi🇮🇳Apollo Hospitals
- P. V. M. Lakshmi🇮🇳Post Graduate Institute of Medical Education and Research
- Ravi Prasad Varma🇮🇳Health Action by People
- Andrés Orlandini🇦🇷Estudios Clínicos Latinoamérica
- Álvaro Avezum🇧🇷Hospital Alemão Oswaldo Cruz; Universidade de Santo Amaro
- Andreas T. Wielgosz🇨🇦University of Ottawa
- Paul Poirier🇨🇦Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval
- Majid Abdularahman Almadi🇸🇦King Saud University
- Yüksel Altuntaş🇹🇷Sağlık Bilimleri Üniversitesi; Şişli Etfal Eğitim ve Araştırma Hastanesi
- Kien Keat Ng🇲🇾National Defence University of Malaysia
- Jephat Chifamba🇿🇼University of Zimbabwe
- Karen Yeates🇨🇦Queen's University
- Thandi Rose Puoane🇿🇦University of the Western Cape
- Rasha Khatib🇵🇸Birzeit University
- Rita Yusuf🇧🇩🇺🇸Independent University, Bangladesh; Advocate Health Care
- Kristina Bengtsson Boström🇸🇪University of Gothenburg
- Katarzyna Zatońska🇵🇱Wroclaw Medical University
- Romaina Iqbal🇵🇰Aga Khan University
- Liu Weida🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Zhu Yibing🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Sidong Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Antonio Miguel L. Dans🇵🇭University of the Philippines Manila
- Afzalhussein Yusufali🇦🇪Dubai Health Authority
- Noushin Mohammadifard🇮🇷Isfahan University of Medical Sciences
- John Kenneth Marshall🇨🇦Population Health Research Institute; McMaster University
- Paul Moayyedi🇨🇦Population Health Research Institute; Hamilton Health Sciences; McMaster University
- Walter Reinisch🇦🇹Medical University of Vienna
- Salim Yusuf🇨🇦Population Health Research Institute; Hamilton Health Sciences; McMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD).
Design
Prospective cohort study.
Setting
21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China).
Participants
116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years.
Main outcome measures
The main outcome was development of IBD, including Crohn's disease or ulcerative colitis. Associations between ultra-processed food intake and risk of IBD were assessed using Cox proportional hazard multivariable models. Results are presented as hazard ratios with 95% confidence intervals.
Results
Participants were enrolled in the study between 2003 and 2016. During the median follow-up of 9.7 years (interquartile range 8.9-11.2 years), 467 participants developed incident IBD (90 with Crohn's disease and 377 with ulcerative colitis). After adjustment for potential confounding factors, higher intake of ultra-processed food was associated with a higher risk of incident IBD (hazard ratio 1.82, 95% confidence interval 1.22 to 2.72 for ≥5 servings/day and 1.67, 1.18 to 2.37 for 1-4 servings/day compared with <1 serving/day, P=0.006 for trend). Different subgroups of ultra-processed food, including soft drinks, refined sweetened foods, salty snacks, and processed meat, each were associated with higher hazard ratios for IBD. Results were consistent for Crohn's disease and ulcerative colitis with low heterogeneity. Intakes of white meat, red meat, dairy, starch, and fruit, vegetables, and legumes were not associated with incident IBD.
Conclusions
Higher intake of ultra-processed food was positively associated with risk of IBD. Further studies are needed to identify the contributory factors within ultra-processed foods.
Study registration
ClinicalTrials.gov NCT03225586.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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