The effects of Ramadan intermittent fasting on liver function in healthy adults: A systematic review, meta-analysis, and meta-regression
Faris M, Jahrami H, Abdelrahim D, Bragazzi N, BaHammam A
Diabetes research and clinical practice · 51 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-07-14 · Diabetes Res Clin Pract · vol. 178 · pág. 108951
- Editorial
- Elsevier BV
- Citado
- 75 citas · más que el 90% de estudios similares · 2.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 142 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Enhanced Recovery After Surgery
- Palabras clave
- Ramadan fasting, intermittent fasting, liver function tests, liver enzymes, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, bilirubin, lactate dehydrogenase, prothrombin time, fasting duration, healthy adults
- MeSH
- liver, humans, alanine transaminase, aspartate aminotransferases, liver function tests, fasting, adult
5 autores
- MoezAlIslam E. Faris🇦🇪 · autor de correspondenciaUniversity of Sharjah
- Haitham Jahrami🇧🇭Ministry of Health; Arabian Gulf University
- Dana N. Abdelrahim🇯🇴University of Jordan
- Nicola Luigi Bragazzi🇨🇦York University
- Ahmed Salem BaHammam🇸🇦King Saud University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Growing evidence is suggestive that intermittent fasting likely to improve liver function; however, still the evidences are controversial to draw a definitive conclusion. Therefore, we conducted a systematic review and meta-analysis to estimate the effect size for changes in liver function tests (LFT) in healthy people practicing Ramadan diurnal intermittent fasting (RDIF), and to examine the impact of different covariates using subgroup analysis and meta-regression.
Methods
Scientific databases were searched from date of inception in 1950 to the end of July 2020. The liver function tests searched and analyzed were aspartate transaminase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), bilirubin (BLU), L-lactate dehydrogenase (LDH) and prothrombin time (PT).
Results
Twenty studies (601 adult participants in total, aged 18-57 years) conducted in 10 countries between 1987 and 2020 were identified. RDIF-induced effect sizes for the LFT expressed as standardized mean difference (SMD) [95% confidence interval] were: AST (no. of studies K = 16, number of subjects N = 502, SMD = -0.257 [-0.381, -0.133], I2 = 42%); ALT (K = 16, N = 502, SMD = -0.105 [-0.282, 0.07], I2 = 71%); GGT (K = 2, N = 46, SMD = -0.533 [-0.842, -0.224], I2 = 0%); ALP (K = 10, N = 312, SMD = -0.318 [-0.432, -0.204], I2 = 0.0%); BLU (K = 10, N = 325, SMD = -0.264 [-0.520, -0.007], I2 = 70.1%); LDH (K = 5, N = 145, SMD = -0.041 [-0.380, 0.298], I2 = 72%); PT (K = 2, N = 74, SMD = -0.027 [-0.732, 0.678], I2 = 87%).
Conclusion
RDIF induces significant but small (AST, ALP, BLU) to medium (GGT) positive changes on LFT, and may confer a transient, short-term protection against fatty liver disease in healthy subjects.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.