Acute Effects of Dietary Nitrate on Exercise Tolerance, Muscle Oxygenation, and Cardiovascular Function in Patients With Peripheral Arterial Disease
van der Avoort CMT, van Loon LJC, Verdijk LB, Poyck PPC, Thijssen DTJ, Hopman MTE
International journal of sport nutrition and exercise metabolism · 13 citas
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Alimentación controladaFinanciación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2021-07-20 · Int J Sport Nutr Exerc Metab · vol. 31 · número 5 · págs. 385–396
- Editorial
- Human Kinetics
- Citado
- 18 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Peripheral Artery Disease Management · Cardiovascular Health and Disease Prevention · Cerebrovascular and Carotid Artery Diseases
- Palabras clave
- Medicine, Arterial stiffness, Nitrate, Blood pressure, Claudication, Crossover study, Placebo, Cardiology, Oxygenation, Nitrite, Internal medicine, Dietary Nitrate, Surgery, Arterial disease, Chemistry, Vascular disease, Pathology
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, cross-over studies, double-blind method, blood pressure, exercise tolerance, dietary supplements, aged, aged, 80 and over, peripheral arterial disease, fruit and vegetable juices
6 autores
- Cindy M.T. van der Avoort🇳🇱🇺🇸HAN University of Applied Sciences; Radboud University Nijmegen; Maastricht University Medical Centre; University Medical Center; Radboud University Medical Center
- Luc J. C. van Loon🇳🇱HAN University of Applied Sciences; Maastricht University Medical Centre
- Lex B. Verdijk🇳🇱Maastricht University Medical Centre
- Paul P. C. Poyck
- Dick T.J. Thijssen🇳🇱🇺🇸🇬🇧Radboud University Nijmegen; University Medical Center; Radboud University Medical Center; Liverpool John Moores University
- Maria T. E. Hopman🇳🇱🇺🇸Radboud University Nijmegen; University Medical Center; Radboud University Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Previous studies have used supplements to increase dietary nitrate intake in clinical populations. Little is known about whether effects can also be induced through vegetable consumption. Therefore, the aim of this study was to assess the impact of dietary nitrate, through nitrate-rich vegetables (NRV) and beetroot juice (BRJ) supplementation, on plasma nitrate and nitrite concentrations, exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease. In a randomized crossover design, 18 patients with peripheral arterial disease (age: 73 ± 8 years) followed a nitrate intake protocol (∼6.5 mmol) through the consumption of NRV, BRJ, and nitrate-depleted BRJ (placebo). Blood samples were taken, blood pressure and arterial stiffness were measured in fasted state and 150 min after intervention. Each intervention was followed by a maximal walking exercise test to determine claudication onset time and peak walking time. Gastrocnemius oxygenation was measured by near-infrared spectroscopy. Blood samples were taken and blood pressure was measured 10 min after exercise. Mean plasma nitrate and nitrite concentrations increased (nitrate; Time × Intervention interaction; p < .001), with the highest concentrations after BRJ (494 ± 110 μmol/L) compared with NRV (202 ± 89 μmol/L) and placebo (80 ± 19 μmol/L; p < .001). Mean claudication onset time and peak walking time did not differ between NRV (413 ± 187 s and 745 ± 220 s, respectively), BRJ (392 ± 154 s and 746 ± 176 s), and placebo (403 ± 176 s and 696 ± 222 s) (p = .762 and p = .165, respectively). Gastrocnemius oxygenation, blood pressure, and arterial stiffness were not affected by the intervention. NRV and BRJ intake markedly increase plasma nitrate and nitrite, but this does not translate to improved exercise tolerance, muscle oxygenation, and/or cardiovascular function.
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