Sauna dehydration as a new physiological challenge model for intestinal barrier function
Roca Rubio MF, Eriksson U, Brummer RJ, König J
Scientific reports · 14 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Örebro Universitet
- Organización sin fines de lucro
- Knowledge Foundation
- Universidad u hospital
- Örebro University
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-07-30 · Sci Rep · vol. 11 · número 1 · pág. 15514
- Editorial
- Nature Portfolio
- Citado
- 15 citas · más que el 80% de estudios similares · 1.4× el promedio de su campo
- Referencias
- 76 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Thermoregulation and physiological responses · Diet and metabolism studies
- Palabras clave
- Intestinal permeability, Barrier function, Dehydration, Lipopolysaccharide, In vivo, Internal medicine, Lipopolysaccharide binding protein, Chemistry, Tight junction, Medicine, Endocrinology, Inflammation, Biochemistry, Biology, Acute-phase protein, Cell biology
- MeSH
- liver, humans, tumor necrosis factor-alpha, acute-phase proteins, carrier proteins, membrane glycoproteins, anti-inflammatory agents, non-steroidal, interleukin-6, interleukin-10, steam bath, temperature, biomedical research, adult, female, male, fatty acid-binding proteins, young adult, lipopolysaccharide-binding protein
4 autores
- Maria Fernanda Roca Rubio🇸🇪 · autor de correspondenciaÖrebro University
- Ulrika Eriksson🇸🇪Örebro University
- Robert J. Brummer🇸🇪Örebro University
- Julia König🇸🇪Örebro University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The intestinal barrier plays a crucial role in maintaining gut health, and an increased permeability has been linked to several intestinal and extra-intestinal disorders. There is an increasing demand for interventions aimed at strengthening this barrier and for in vivo challenge models to assess their efficiency. This study investigated the effect of sauna-induced dehydration on intestinal barrier function (clinicaltrials.gov: NCT03620825). Twenty healthy subjects underwent three conditions in random order: (1) Sauna dehydration (loss of 3% body weight), (2) non-steroidal anti-inflammatory drug (NSAID) intake, (3) negative control. Intestinal permeability was assessed by a multi-sugar urinary recovery test, while intestinal damage, bacterial translocation and cytokines were assessed by plasma markers. The sauna dehydration protocol resulted in an increase in gastroduodenal and small intestinal permeability. Presumably, this increase occurred without substantial damage to the enterocytes as plasma intestinal fatty acid-binding protein (I-FABP) and liver fatty acid-binding protein (L-FABP) were not affected. In addition, we observed significant increases in levels of lipopolysaccharide-binding protein (LBP), IL-6 and IL-8, while sCD14, IL-10, IFN-ɣ and TNF-α were not affected. These results suggest that sauna dehydration increased intestinal permeability and could be applied as a new physiological in vivo challenge model for intestinal barrier function.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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