Psychoneuroendocrinological effects of music therapy versus mindfulness in palliative care: results from the 'Song of Life' randomized controlled trial
Koehler F, Kessler J, Stoffel M, Weber M, Bardenheuer HJ, Ditzen B, Warth M
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitätsklinikum Heidelberg
- Organización sin fines de lucro
- Hector Stiftung
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-08-06 · Support Care Cancer · vol. 30 · número 1 · págs. 625–634
- Editorial
- Springer Science+Business Media
- Citado
- 19 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Music Therapy and Health · Palliative Care and End-of-Life Issues · Palliative and Oncologic Care
- Palabras clave
- music therapy, mindfulness, palliative care, subjective distress, cortisol, alpha-amylase, heart rate, heart rate variability, stress biomarkers, psychoneuroendocrinology, autonomic nervous system, psychosocial interventions
- MeSH
- humans, music therapy, palliative care, heart rate, music, hospice and palliative care nursing, mindfulness
7 autores
- Friederike Koehler🇩🇪Heidelberg University; University Hospital Heidelberg
- Jens Keßler🇩🇪Heidelberg University; University Hospital Heidelberg
- Martin Stoffel🇩🇪Heidelberg University; University Hospital Heidelberg
- Martin Weber🇩🇪Johannes Gutenberg University Mainz; University Medical Center of the Johannes Gutenberg University Mainz
- Hubert J. Bardenheuer🇩🇪Heidelberg University; University Hospital Heidelberg
- Beate Ditzen🇩🇪Heidelberg University; University Hospital Heidelberg
- Marco Warth🇩🇪 · autor de correspondenciaHeidelberg University; University Hospital Heidelberg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Although research on psychosocial interventions in palliative care provided evidence for their effectiveness regarding patient-reported outcomes, few studies have examined their psychobiological effects yet. Therefore, the purpose of the present work as part of an overarching study was to investigate differential effects of music therapy versus mindfulness on subjective distress and both neuroendocrine and autonomic stress biomarkers.
Methods
A total of 104 patients from two palliative care units were randomly assigned to three sessions of either music therapy or mindfulness. Before and after the second session (completed by 89 patients), participants rated their momentary distress and provided three saliva samples for cortisol and α-amylase analysis. Furthermore, photoplethysmography recordings were continuously assessed to calculate mean heart rate and heart rate variability. Data were analyzed using multilevel modeling of all available data and sensitivity analysis with multiply imputed data.
Results
Between 67 and 75% of the maximally available data points were included in the primary analyses of psychobiological outcomes. Results showed a significant time*treatment effect on distress (b = - 0.83, p = .02) indicating a greater reduction in the music therapy group. No interaction effects were found in psychobiological outcomes (all p > .05), but multilevel models revealed a significant reduction in cortisol (b = - 0.06, p = .01) and mean heart rate (b = - 7.89, p = .05) over time following either intervention.
Conclusion
Findings suggest a beneficial effect music therapy on distress while no differential psychobiological treatment effects were found. Future studies should continue to investigate optimal stress biomarkers for psychosocial palliative care research.
Trial registration
German Clinical Trials Register (DRKS)-DRKS00015308 (date of registration: September 7, 2018).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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