Intermittent fasting versus continuous energy-restricted diet for patients with type 2 diabetes mellitus and metabolic syndrome for glycemic control: A systematic review and meta-analysis of randomized controlled trials
Wang X, Li Q, Liu Y, Jiang H, Chen W
Diabetes research and clinical practice · 55 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Beijing Municipal Science and Technology Commission
- Subvenciones
- Beijing Municipal Science and Technology Commission (Z191100008619006)
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-08-12 · Diabetes Res Clin Pract · vol. 179 · pág. 109003
- Editorial
- Elsevier BV
- Citado
- 78 citas · más que el 89% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Diet and metabolism studies · Diabetes Management and Research
- Palabras clave
- intermittent fasting, type 2 diabetes, metabolic syndrome, glycemic control, weight loss, HbA1c, fasting blood glucose, fasting insulin, lipid profile, hypoglycemia, obesity
- MeSH
- humans, diabetes mellitus, type 2, blood glucose, diet, fasting, randomized controlled trials as topic, metabolic syndrome
5 autores
- Xue Wang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Qifei Li🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Yan Liu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
- Hua Jiang🇨🇳University of Electronic Science and Technology of China; Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
- Wei Chen🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Peking Union Medical College Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To compare the safety of intermittent fasting (IF) with that of continuous energy-restricted diets (CERD) in patients with T2DM and metabolic syndrome who were overweight or obese and assess their effects on glycemic control and weight loss.
Materials and methods
We searched MEDLINE (Ovid), Embase, and SINOMED databases up to September 13, 2020. The major outcome was glycemic control and secondary outcomes were change in weight, fasting insulin, and lipid profile.
Results
Of 84 retrieved studies, 5 met our inclusion criteria. Of these, four studies comprising 355 participants were included in the meta-analysis. Based on changes in HbA1c (-0.06, 95% confidence interval [CI] -0.27 to 0.16) and fasting plasma glucose (-0.27, 95% CI -0.76 to 0.22), IF and CERD had similar effects on glycemic control. Moreover, IF had a better effect on weight loss (-1.70, 95% CI -3.28 to -0.11 kg). Patients in both groups experienced similar improvements in fasting insulin and lipid profile as well as similar hypoglycemic events.
Conclusions
IF is a safe diet pattern and could be implemented for patients with T2DM or metabolic syndrome. Further studies with a larger sample size are needed to verify the effectiveness and safety of IF in patients with T2DM.
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