An extra virgin olive oil-enriched chocolate spread positively modulates insulin-resistance markers compared with a palm oil-enriched one in healthy young adults: A double-blind, cross-over, randomised controlled trial
Tuccinardi D, Di Mauro A, Lattanzi G, Rossini G, Monte L, Beato I, Spiezia C, Bravo M, Watanabe M, Soare A, Kyanvash S, Armirotti A, Bertozzi SM, Gastaldelli A, Pedone C, Khazrai YM, Pozzilli P, Manfrini S
Diabetes/metabolism research and reviews · 16 citas
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Cómo se estudió
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- Marcadores de salud y funcionamiento
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Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-08-26 · Diabetes Metab Res Rev · vol. 38 · número 2 · pág. e3492
- Editorial
- Wiley
- Citado
- 24 citas · más que el 84% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Diet, Metabolism, and Disease · Edible Oils Quality and Analysis
- Palabras clave
- extra virgin olive oil, palm oil, chocolate spread, monounsaturated fatty acids, saturated fatty acids, insulin resistance, sphingolipids, plasma ceramides, sphingomyelin, glucose metabolism, isocaloric diet, young adults, fat replacement
- MeSH
- humans, insulin resistance, cross-over studies, adult, young adult, insulins, olive oil, chocolate, palm oil
18 autores
- Dario Tuccinardi🇮🇹Università Campus Bio-Medico
- Antonio Di Mauro🇮🇹Università Campus Bio-Medico
- Greta Lattanzi🇮🇹Università Campus Bio-Medico
- Giovanni Rossini🇮🇹Università Campus Bio-Medico
- Lavinia Monte🇮🇹Università Campus Bio-Medico
- Ivan Beato🇮🇹Università Campus Bio-Medico
- Chiara Spiezia🇮🇹Università Campus Bio-Medico
- Maria Bravo🇮🇹Università Campus Bio-Medico
- Mikiko Watanabe🇮🇹Sapienza University of Rome
- Andreea Soare🇮🇹Università Campus Bio-Medico
- Shadi Kyanvash🇮🇹Università Campus Bio-Medico
- Andrea Armirotti🇮🇹Italian Institute of Technology
- Sine Mandrup Bertozzi🇮🇹Italian Institute of Technology
- Amalia Gastaldelli🇮🇹Istituto di Fisiologia Clinica; National Research Council
- Claudio Pedone🇮🇹Università Campus Bio-Medico
- Yeganeh Manon Khazrai🇮🇹Università Campus Bio-Medico
- Paolo Pozzilli🇮🇹🇬🇧Università Campus Bio-Medico; Queen Mary University of London
- Silvia Manfrini🇮🇹 · autor de correspondenciaUniversità Campus Bio-Medico
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
To investigate if extra virgin olive oil (EVOO) or palm oil enriched chocolate spreads consumption leads to different results in terms of plasma ceramides concentration, glucose and lipid metabolism, inflammatory markers and appetite regulation in young healthy subjects.
Methods
In a 2-week, double-blind, cross-over, randomised controlled trial, 20 healthy, normal-weight subjects with a mean age of 24.2 years (SD: 1.2), consumed chocolate spread snacks (73% of energy [%E] from fat, 20% from carbohydrates and 7% from proteins), providing 570 Kcal/day added to an isocaloric diet. The chocolate spreads were identical, except for the type of fat: EVOO oil, rich in monounsaturated fatty acids (MUFAs), or palm oil, rich in Saturated Fatty Acids (SFAs).
Results
EVOO-enriched chocolate spread consumption led to better circulating sphingolipids and glucose profile, with reduced plasma ceramide C16:0, ceramide C16:0/ceramide C22:0-ceramide C24:0 ratio and sphingomyelin C18:0 (P = 0.030, P= 0.032 and P = 0.042, respectively) compared to the palm oil-enriched chocolate spread diet. HOMA-IR and plasma insulin were lower, while the Quicki and the McAuley Index were higher after the EVOO diet compared to the palm oil diet (P = 0.046, P = 0.045, P = 0.018 and P = 0.039 respectively). Subjects maintained a stable weight throughout the study. No major significant changes in total cholesterol, triglycerides, HDL, inflammatory markers, and appetite-regulating hormones/visual analogue scale were observed between the groups.
Conclusions
Partially replacing SFAs with MUFAs in a chocolate-based snack as part of a short-term isocaloric diet in healthy individuals may limit SFAs detrimental effects on insulin sensitivity and decrease circulating harmful sphingolipids in young adults.
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