Chronic Dialysis Patients Are Depleted of Creatine: Review and Rationale for Intradialytic Creatine Supplementation
van der Veen Y, Post A, Kremer D, Koops CA, Marsman E, Appeldoorn TYJ, Touw DJ, Westerhuis R, Heiner-Fokkema MR, Franssen CFM, Wallimann T, Bakker SJL
Nutrients · 13 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitair Medisch Centrum Groningen
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-08-06 · Nutrients · vol. 13 · número 8 · pág. 2709
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 20 citas · más que el 75% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 86 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Dialysis and Renal Disease Management · Nutrition and Health in Aging
- Palabras clave
- Creatine, Medicine, Hemodialysis, Kidney disease, Dialysis, Internal medicine, Creatinine, Creatine Monohydrate, Placebo, Intensive care medicine, Urinary system, Endocrinology, Pathology
- MeSH
- humans, creatine, treatment outcome, renal dialysis, pilot projects, double-blind method, health status, time factors, dietary supplements, netherlands, renal insufficiency, chronic, randomized controlled trials as topic
12 autores
- Yvonne van der Veen🇳🇱 · autor de correspondenciaUniversity Medical Center Groningen; University of Groningen
- Adrian Post🇳🇱 · autor de correspondenciaUniversity Medical Center Groningen; University of Groningen
- Daan Kremer🇳🇱University Medical Center Groningen; University of Groningen
- Christa A. Koops🇳🇱University Medical Center Groningen; University of Groningen
- E. Madelief Marsman🇳🇱Dialyse Centrum Groningen
- Theo Y. Jerôme Appeldoorn🇳🇱University Medical Center Groningen; University of Groningen
- Daan Johannes Touw🇳🇱University Medical Center Groningen; University of Groningen
- Ralf Westerhuis🇳🇱Dialyse Centrum Groningen
- Margaretha Rebecca Heiner-Fokkema🇳🇱University Medical Center Groningen; University of Groningen
- Casper F. M. Franssen🇳🇱University Medical Center Groningen; University of Groningen
- Theo Wallimann🇨🇭ETH Zurich
- Stephan J. L. Bakker🇳🇱 · autor de correspondenciaUniversity Medical Center Groningen; University of Groningen
Resumen
El texto original del estudio, en el idioma en que se publicó.
There is great need for the identification of new, potentially modifiable risk factors for the poor health-related quality of life (HRQoL) and of the excess risk of mortality in dialysis-dependent chronic kidney disease patients. Creatine is an essential contributor to cellular energy homeostasis, yet, on a daily basis, 1.6-1.7% of the total creatine pool is non-enzymatically degraded to creatinine and subsequently lost via urinary excretion, thereby necessitating a continuous supply of new creatine in order to remain in steady-state. Because of an insufficient ability to synthesize creatine, unopposed losses to the dialysis fluid, and insufficient intake due to dietary recommendations that are increasingly steered towards more plant-based diets, hemodialysis patients are prone to creatine deficiency, and may benefit from creatine supplementation. To avoid problems with compliance and fluid balance, and, furthermore, to prevent intradialytic losses of creatine to the dialysate, we aim to investigate the potential of intradialytic creatine supplementation in improving outcomes. Given the known physiological effects of creatine, intradialytic creatine supplementation may help to maintain creatine homeostasis among dialysis-dependent chronic kidney disease patients, and consequently improve muscle status, nutritional status, neurocognitive status, HRQoL. Additionally, we describe the rationale and design for a block-randomized, double-blind, placebo-controlled pilot study. The aim of the pilot study is to explore the creatine uptake in the circulation and tissues following different creatine supplementation dosages.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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