Impact of dietary nitrate supplementation on exercise capacity and cardiovascular parameters in chronic respiratory disease: a systematic review and meta-analysis
Alsulayyim AS, Alasmari AM, Alghamdi SM, Polkey MI, Hopkinson NS
BMJ open respiratory research · 9 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Jazan University
Según 1 financiador declarado.
Publicación
- Publicado
- 2021-09-01 · BMJ Open Respir Res · vol. 8 · número 1 · pág. e000948
- Editorial
- BMJ
- Citado
- 11 citas · más que el 59% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention
- Palabras clave
- nitrate supplementation, beetroot juice, chronic respiratory disease, exercise capacity, blood pressure, pulmonary rehabilitation, cardiovascular parameters, endothelial function
- MeSH
- humans, nitrates, exercise, blood pressure, exercise tolerance, dietary supplements
5 autores
- Abdullah S Alsulayyim🇬🇧🇸🇦Imperial College London; Jazan University
- Ali Alasmari🇸🇦🇬🇧Taibah University; Imperial College London
- Saeed M. Alghamdi🇸🇦🇬🇧Umm al-Qura University; Imperial College London
- Michael Iain Polkey🇬🇧Imperial College London
- Nicholas S Hopkinson🇬🇧 · autor de correspondenciaImperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dietary nitrate supplementation, usually in the form of beetroot juice, may improve exercise performance and endothelial function. We undertook a systematic review and meta-analysis to establish whether this approach has beneficial effects in people with respiratory disease.
Methods
A systematic search of records up to March 2021 was performed on PubMed, CINAHL, MEDLINE (Ovid), Cochrane and Embase to retrieve clinical trials that evaluated the efficacy of dietary nitrate supplementation on cardiovascular parameters and exercise capacity in chronic respiratory conditions. Two authors independently screened titles, abstracts and full texts of potential studies and performed the data extraction.
Results
After full-text review of 67 papers, eleven (two randomised controlled trials and nine crossover trials) involving 282 participants met the inclusion criteria. Three were single dose; seven short term; and one, the largest (n=122), done in the context of pulmonary rehabilitation. Pooled analysis showed that dietary nitrate supplementation reduced systolic blood pressure (BP), diastolic BP and mean arterial pressure (mean difference (95% CI), -3.39 mm Hg (-6.79 to 0.01); p=0.05 and -2.20 mm Hg (-4.36 to -0.03); p=0.05 and -4.40 mm Hg (-7.49 to -1.30); p=0.005, respectively). It was associated with increased walk distance in the context of pulmonary rehabilitation (standardised mean difference (95% CI), 0.47 (0.11 to 0.83), p=0.01), but no effect was identified in short-term studies (0.08 (-0.32 to 0.49).
Conclusion
Dietary nitrate supplementation may have a beneficial effect on BP and augment the effect of pulmonary rehabilitation on exercise capacity. Short-term studies do not suggest a consistent benefit on exercise capacity.
Prospero registration number
CRD42019130123.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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