Magnesium intake and vascular structure and function: the Hoorn Study
Vermeulen EA, de Jong HBT, Blomjous AGA, Eelderink C, Hoekstra T, Elders PJM, de Borst MH, Vervloet MG, van Ballegooijen AJ, Beulens JW
European journal of nutrition · 6 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- ZonMw
- Organización sin fines de lucro
- Nierstichting
- Organización sin fines de lucro
- Diabetes Fonds
- Gobierno
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Gobierno
- ZonMW NWO-Vidi grant
- Organización sin fines de lucro
- Dutch Diabetes Research Foundation
- Gobierno
- Health Holland
- Subvenciones
- Diabetes Fonds (2005.00.010); Nederlandse Organisatie voor Wetenschappelijk Onderzoek (91 71 8304); Nierstichting (16TKI02); ZonMw (91718304); Diabetes Fonds (2003.01.004); Diabetes Fonds (2005.00.010, 2003.01.004)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2021-09-07 · Eur J Nutr · vol. 61 · número 2 · págs. 653–664
- Editorial
- Springer Science+Business Media
- Citado
- 7 citas · más que el 62% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 65 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Cardiovascular Health and Disease Prevention · Parathyroid Disorders and Treatments
- Palabras clave
- Medicine, Prospective cohort study, Pulse wave velocity, Cohort, Internal medicine, Cohort study, Confidence interval, Logistic regression, Population, Cardiology, Blood pressure, Environmental health
- MeSH
- humans, magnesium, risk factors, prospective studies, cross-sectional studies, carotid intima-media thickness, vascular stiffness, pulse wave analysis
10 autores
- Emma A. Vermeulen🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Hanne B. T. de Jong🇳🇱Wageningen University & Research
- Alexander G. A. Blomjous🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Coby Eelderink🇳🇱University Medical Center Groningen; University of Groningen
- Tiny Hoekstra🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Petra J. M. Elders🇳🇱Amsterdam Public Health; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Martin H. de Borst🇳🇱University Medical Center Groningen; University of Groningen
- Marc G. Vervloet🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Adriana Johanne van Ballegooijen🇳🇱Amsterdam UMC Location Vrije Universiteit Amsterdam
- Joline W. J. Beulens🇳🇱 · autor de correspondenciaAmsterdam University Medical Centers; Amsterdam UMC Location Vrije Universiteit Amsterdam
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the association between dietary magnesium intake and several measures of vascular structure and function in a prospective cohort.
Methods
We included 789 participants who participated in the vascular screening sub-cohort of the Hoorn Study, a population-based, prospective cohort study. Baseline dietary magnesium intake was estimated with a validated food frequency questionnaire and categorised in energy-adjusted magnesium intake tertiles. Several measurements of vascular structure and function were performed at baseline and most measurements were repeated after 8 years of follow-up (n = 432). Multivariable linear and logistic regression was performed to study the cross-sectional and longitudinal associations of magnesium intake and intima-media thickness (IMT), augmentation index (Aix), pulse wave velocity (PWV), flow-mediated dilatation (FMD), and peripheral arterial disease (PAD).
Results
Mean absolute magnesium intake was 328 ± 83 mg/day and prior CVD and DM2 was present in 55 and 41% of the participants, respectively. Multivariable regression analyses did not demonstrate associations between magnesium intake and any of the vascular outcomes. Participants in the highest compared to the lowest magnesium intake tertile demonstrated in fully adjusted cross-sectional analyses a PWV of -0.21 m/s (95% confidence interval -1.95, 1.52), a FMD of -0.03% (-0.89, 0.83) and in longitudinal analyses an IMT of 0.01 mm (-0.03, 0.06), an Aix of 0.70% (-1.69, 3.07) and an odds ratio of 0.84 (0.23, 3.11) for PAD CONCLUSION: We did not find associations between dietary magnesium intake and multiple markers of vascular structure and function, in either cross-sectional or longitudinal analyses.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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