Financiado en parte por Nutrition Research Foundation—DSM Research Fund
Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease in the Tianjin Chronic Low-grade Systemic Inflammation and Health Cohort Study
Zhang S, Gan S, Zhang Q, Liu L, Meng G, Yao Z, Wu H, Gu Y, Wang Y, Zhang T, Wang X, Sun S, Wang X, Zhou M, Jia Q, Song K, Qi L, Niu K
International journal of epidemiology · 93 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- National Natural Science Foundation of China
- Empresa
- Nutrition Research Foundation—DSM Research Fund
- Gobierno
- National Health Commission of China
- Gobierno
- National Key Research and Development Project-Study on Diet and Nutrition Assessment and Intervention Technology
- Subvenciones
- National Natural Science Foundation of China (81941024); National Natural Science Foundation of China (81,673,166); National Natural Science Foundation of China (81872611); National Natural Science Foundation of China (91,746,205)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2021-08-01 · Int J Epidemiol · vol. 51 · número 1 · págs. 237–249
- Editorial
- Oxford University Press
- Citado
- 120 citas · más que el 99% de estudios similares · 13.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Obesity, Physical Activity, Diet
- Palabras clave
- Medicine, Hazard ratio, Fatty liver, Body mass index, Confidence interval, Cohort study, Quartile, Internal medicine, Cohort, Prospective cohort study, Proportional hazards model, Environmental health, Disease
- MeSH
- humans, inflammation, diet, risk factors, cohort studies, prospective studies, adolescent, adult, aged, aged, 80 and over, middle aged, female, male, young adult, non-alcoholic fatty liver disease
18 autores
- Shunming Zhang🇨🇳Tianjin Medical University
- Shinan Gan🇨🇳Tianjin Medical University
- Qing Zhang🇨🇳Tianjin Medical University General Hospital
- Li Liu🇨🇳Tianjin Medical University General Hospital
- Ge Meng🇨🇳Tianjin Medical University
- Zhanxin Yao🇨🇳Tianjin Medical University
- Hongmei Wu🇨🇳Tianjin Medical University
- Yeqing Gu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College
- Yawen Wang🇨🇳Tianjin Medical University
- Tingjing Zhang🇨🇳Tianjin Medical University
- Xuena Wang🇨🇳Tianjin Medical University General Hospital; Tianjin Medical University
- Shaomei Sun🇨🇳Tianjin Medical University General Hospital
- Xing Wang🇨🇳Tianjin Medical University General Hospital; Tianjin Medical University
- Ming Yue Zhou🇨🇳Tianjin Medical University General Hospital
- Qiyu Jia🇨🇳Tianjin Medical University General Hospital
- Kun Song🇨🇳Tianjin Medical University General Hospital
- Lu Qi🇺🇸Tulane University; Harvard University
- Kaijun Niu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Tianjin Medical University General Hospital; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Growing evidence supports a link between ultra-processed food consumption and human health outcomes. However, the association between ultra-processed food consumption and non-alcoholic fatty liver disease (NAFLD) is not known. We aimed to explore the association between ultra-processed food consumption and risk of NAFLD.
Methods
The prospective study included 16 168 participants aged 18-90 years from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) Cohort Study. Information on ultra-processed food consumption was collected at baseline using a validated food frequency questionnaire. NAFLD was defined as the presence of sonographic fatty liver in the absence of significant alcohol intake (≥210 g/week for men and ≥140 g/week for women, respectively) and other liver diseases. Multivariable Cox proportional hazards models were used to examine the association between ultra-processed food consumption and risk of NAFLD.
Results
During 56 935 person-years of follow-up, we documented 3752 incident NAFLD cases. After adjusting for age, sex, body mass index, smoking, alcohol drinking, education, occupation, income, physical activity, total energy intake, personal and family history of disease and overall diet quality, the multivariable hazard ratios (95% confidence interval) of NAFLD across increasing quartiles of ultra-processed food consumption were 1.00 (reference), 0.99 (0.90, 1.08), 1.13 (1.03, 1.25) and 1.18 (1.07, 1.30), respectively (P for trend <0.0001). The hazard ratio (95% confidence interval) per one standard deviation increase in ultra-processed food consumption, equivalent to a 62.7 g/1000 kcal per day, was 1.06 (1.03, 1.09), P = 0.0001.
Conclusions
Our study indicates that higher ultra-processed food consumption is associated with a higher risk of NAFLD. This finding suggests that ultra-processed food, which is widely consumed worldwide, might be a modifiable dietary target to reduce the risk of NAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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