Effect of Magnesium Supplementation on Chronic Kidney Disease-Mineral and Bone Disorder in Hemodialysis Patients: A Meta-Analysis of Randomized Controlled Trials
Guo G, Zhou J, Xu T, Sheng Z, Huang A, Sun L, Yao L
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 16 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Shenyang Science and Technology Bureau
- Subvenciones
- National Natural Science Foundation of China (82070763); Shenyang Science and Technology Bureau (19-112-4-031)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2021-09-14 · J Ren Nutr · vol. 32 · número 1 · págs. 102–111
- Editorial
- Elsevier BV
- Citado
- 22 citas · más que el 60% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Dialysis and Renal Disease Management
- Palabras clave
- magnesium supplementation, chronic kidney disease-mineral and bone disorder, hemodialysis, parathyroid hormone, serum calcium, serum phosphorus, carotid intima-media thickness, dialysate magnesium, oral magnesium, C-reactive protein
- MeSH
- humans, magnesium, renal dialysis, dietary supplements, randomized controlled trials as topic, carotid intima-media thickness, chronic kidney disease-mineral and bone disorder
7 autores
- Guangying Guo🇨🇳First Hospital of China Medical University
- Junlei Zhou🇨🇳First Hospital of China Medical University
- Tianhua Xu🇨🇳First Hospital of China Medical University
- Zitong Sheng🇨🇳First Hospital of China Medical University
- Aoran Huang🇨🇳First Hospital of China Medical University
- Li Sun🇨🇳 · autor de correspondenciaFirst Hospital of China Medical University; China Medical University
- Li Yao🇨🇳 · autor de correspondenciaFirst Hospital of China Medical University; China Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Research about the effects of magnesium (Mg) supplementation on chronic kidney disease-mineral bone disorder (CKD-MBD) among hemodialysis (HD) patients is controversial. Thus, we conducted a meta-analysis to examine Mg supplementation's effects on CKD-MBD in patients requiring dialysis.
Methods
The PubMed and EMBASE databases were searched for English language studies up to September 2020. The main indicators of our study were changes in serum Mg, calcium (Ca), phosphate, parathyroid hormone (PTH), and C-reactive protein levels, and carotid intima-media thickness (CIMT) after Mg supplementation. Mg efficacy was evaluated by weighted mean difference (WMD) and confidence intervals (CIs), and subgroup analyses of intervention type and intervention duration were also performed.
Results
Eight eligible studies comprising 309 HD patients were included in our meta-analysis. Mg supplementation alone produced a negative effect on serum PTH levels (WMD = -236.56; 95% CI -349.71 to -123.41) and CIMT (WMD = -0.18; 95% CI -0.34 to -0.01). A subgroup analysis based on intervention type showed a significant improvement in serum Mg (WMD = 1.08; 95% CI 0.51-1.64) and Ca (WMD = -0.50; 95% CI -0.77 to -0.23) levels when Mg was administered via dialysate and oral medication, respectively. Different intervention durations had no effect on serum Mg levels. Mg supplementation had no significant effect on serum phosphate (WMD = -0.25; 95% CI -0.64 to 0.14) and C-reactive protein levels (WMD = -0.02; 95% CI -2.80 to 2,76).
Conclusions
Our results showed that Mg supplementation alone could improve CKD-MBD by regulating serum Ca and PTH metabolism and decreasing CIMT among HD patients.
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